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14343 Sigma

1(S),9(R)-(−)-Bicuculline methiodide

≥95.0% (HPCE)

Synonym: (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

  • CAS Number 40709-69-1

  • Empirical Formula (Hill Notation) C21H20INO6

  • Molecular Weight 509.29

  •  Beilstein Registry Number 5419649

  •  MDL number MFCD00078966

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
InChI Key   HKJKCPKPSSVUHY-GRTNUQQKSA-M
assay   ≥95.0% (HPCE)
optical activity   [α]/D -116±6°, c = 1 in chloroform
solubility   H2O: soluble10 mg/mL, almost clear, greenish-yellow
storage temp.   2-8°C

Description

Biochem/physiol Actions

(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.

Preparation Note

prepared from (+)-bicuculline

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

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