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16569 Sigma

4-Bromo-calcium Ionophore A23187

≥95.0% (N)

Synonym: 4-Bromo-A23187, 4-Bromo-calcimycin

  • CAS Number 76455-48-6

  • Empirical Formula (Hill Notation) C29H36BrN3O6

  • Molecular Weight 602.52

  •  MDL number MFCD00077667

  •  PubChem Substance ID 57647578

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents, Interferes with Cell Membrane Permeability (Ionophores),
InChI Key   LDXQFZZGVTWFCF-FHYGWRBKSA-N
assay   ≥95.0% (N)
form   powder or crystals
color   faintly yellow to yellow
solubility   ethanol: 20 mg/mL clear, yellow
Mode of action   cell membrane | interferes
storage temp.   2-8°C

Description

Application

Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.

Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.

Other Notes

In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A23187

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Biochem/physiol Actions

Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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