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17938 Sigma

25-Hydroxyvitamin D3 monohydrate

≥99.0% (HPLC)

Synonym: 25-Hydroxycholecalciferol

  • CAS Number 63283-36-3

  • Empirical Formula (Hill Notation) C27H44O2 · H2O

  • Molecular Weight 418.65

  •  Beilstein Registry Number 4270041

  •  MDL number MFCD00867077

  •  PubChem Substance ID 57647690

  •  eCl@ss 34058003

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Properties

Related Categories Biochemicals and Reagents, Vitamin D, Vitamin D3, Vitamins
InChI Key   JWUBBDSIWDLEOM-DTOXIADCSA-N
assay   ≥99.0% (HPLC)
shipped in   dry ice
storage temp.   −20°C

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).

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Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
Protocols & Articles

Articles

Analysis of Vitamin D in Milk and Infant Formula using UHPLC/MS/MS per AOAC Method 2011.11

Fortification of milk, dairy products, infant and adult nutritionals with vitamin D is required in many countries to provide additional dietary vitamin D. The fortification of milk in the USA, for ex...
Olga Shimelis
Reporter US Volume 33.2
Keywords: Chromatography, Evaporation, High performance liquid chromatography, Mass spectrometry, Metabolites, Sample preparations, Saponifications, Separation, Solvents, Vitamins

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniq...
Chloe McClanahan
BioFiles 2009, 4.6, 4.
Keywords: Absorption, Angiogenesis, Biofiles, Biological processes, Cancer, Clinical, Gene expression, Growth factors, Hormones, Hydroxylations, Ligands, Metabolites, Transcription, Type, Vitamins

Peer-Reviewed Papers
15

References

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