25-Hydroxyvitamin D3 monohydrate ≥99.0% (HPLC)

Properties

Related Categories	Nutrition Research, Vitamin D, Vitamin D3, Vitamins
assay	≥99.0% (HPLC)
storage temp.	−20°C

Description

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).

Price and Availability

Related Papers

Metabolism and molecular mechanism of action of vitamin D: 1981. DeLuca HF. Biochem. Soc. Trans. 10, 147-158, (1982)

Documents

Certificate of Analysis

Safety Information

Symbol	GHS06, GHS08
Signal word	Danger
Hazard statements	H300-H310-H330-H372
Precautionary statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T+
Risk Statements (Europe)	24/25-26-48/25
Safety Statements (Europe)	28-36/37-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniq...
Chloe McClanahan
BioFiles 2009, 4.6, 4.
Keywords: Absorption, Angiogenesis, Biological processes, Cancer, Clinical, Gene expression, Growth factors, Hormones, Hydroxylations, Ligands, Metabolites, Transcription, Vitamins