|Related Categories||Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism, Vitamin D,|
|assay||≥98% (vitamin + pre-vitamin, HPLC)|
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalcif
|Precautionary statements||P264-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||28|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 2811 6.1/PG 2|
24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Yamamoto T, Ozono K, Shima M, et at. Exp. Cell Res. 244, 71-76, (1998)
24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. Hurst-Kennedy J, Zhong M, et al. J. Steroid Biochem. Mol. Biol. 122, 264-271, (2010)
The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. Wagner D, Hanwell HE, Schnabl K, et al. J. Steroid Biochem. Mol. Biol. 126, 72-77, (2011)
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