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17943 Sigma

(24R)-24,25-Dihydroxyvitamin D3

≥98% (vitamin + pre-vitamin, HPLC)

Synonym: (24R)-,24,25-Dihydroxycholecalciferol, Secalciferol

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Metabolic Pathways, Metabolomics, Steroid Metabolism,
InChI Key   FCKJYANJHNLEEP-XRWYNYHCSA-N
assay   ≥98% (vitamin + pre-vitamin, HPLC)
storage temp.   −20°C

Description

Packaging

1 mg in poly bottle

100 μg in poly bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 α-hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca2+, PLD, and PLC signaling and through LPA-LPA1/3-G(αi)-PI(3)K-mdm2-mediated p53 degradation.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
VS2895000
Protocols & Articles
Peer-Reviewed Papers
15

References

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