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  • 17943 - (24R)-24,25-Dihydroxyvitamin D3

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17943 Sigma

(24R)-24,25-Dihydroxyvitamin D3

≥98% (vitamin + pre-vitamin, HPLC)

DOWNLOAD MSDS (PDF)

Synonym: (24R)-,24,25-Dihydroxycholecalciferol, Secalciferol

  • CAS Number 55721-11-4

  • Empirical Formula (Hill Notation) C27H44O3

  • Molecular Weight 416.64

  •  Beilstein Registry Number 4567039

  •  MDL number MFCD00941417

  •  PubChem Substance ID 24850812

(24R)-24,25-Dihydroxyvitamin D3 ≥98% (vitamin + pre-vitamin, HPLC)
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Properties

Related Categories Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism, Vitamin D,
assay   ≥98% (vitamin + pre-vitamin, HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 α-hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca2+, PLD, and PLC signaling and through LPA-LPA1/3-G(αi)-PI(3)K-mdm2-mediated p53 degradation.

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