|Related Categories||Cell Biology, Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism,|
|assay||≥97.0% (sum of vitamin and previtamin, HPLC)|
Bottomless glass bottle. Contents are inside inserted fused cone.
Ergocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1α,25-dihydroxycalciferol
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 17944.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
|Precautionary statements||P261-P280-P301 + P310-P311|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||63-23/24/25|
|Safety Statements (Europe)||36/37-45|
|RIDADR||UN 2811 6.1 / PGII|
Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniq...
BioFiles 2009, 4.6, 4.
Keywords: Absorption, Angiogenesis, Biological processes, Cancer, Clinical, Gene expression, Growth factors, Hormones, Hydroxylations, Ligands, Metabolites, Transcription, Vitamins
Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Sochorová K, Budinský V, Rozková D, et al. Clin. Immunol. 133, 69-77, (2009)
Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Ströhle A, Wolters M, Hahn A. Inflamm. Allergy Drug Targets 10, 54-63, (2011)
Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model. Wietrzyk J, Nevozhay D, Milczarek M, et al. Cancer Chemother. Pharmacol. 62(5), 787-97, (2008)
Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3. Wang Q, Wang X, and Studzinski GP J. Cell. Biochem. 89(6), 1087-101, (2003)
Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners. Chodyński M, Wietrzyk J, Marcinkowska E, et al. Steroids 67(9), 789-98, (2002)
Relative potencies of 1,25-(OH)(2)D(3) and 19-Nor-1,25-(OH)(2)D(2) on inducing differentiation and markers of bone formation in MG-63 cells. Finch JL, Dusso AS, Pavlopoulos T, et al. J. Am. Soc. Nephrol. 12(7), 1468-74, (2001)
Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. Biancuzzo RM, Clarke N, Reitz RE, et al. J. Clin. Endocrinol. Metab. 98(3), 973-9, (2013)
Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period. O'Brien KO, Donangelo CM, Ritchie LD, et al. Am. J. Clin. Nutr. 96(1), 64-72, (2012)
Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry. Sudsakorn S, Phatarphekar A, O'Shea T, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(2), 139-45, (2011)
The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Egbuna O, Quinn S, Kantham L, et al. Am. J. Physiol. Renal Physiol. 297(3), F720-8, (2009)
Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. Masuda S, Strugnell SA, Knutson JC, et al. Biochim. Biophys. Acta 1761(2), 221-34, (2006)
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