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17946 Sigma

1α-Hydroxyvitamin D3

≥97.0% (HPLC)

Synonym: 1α-Hydroxycholecalciferol, Alfacalcidol

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Properties

Related Categories Cell Biology, Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism,
InChI Key   OFHCOWSQAMBJIW-AVJTYSNKSA-N
assay   ≥97.0% (HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
VS2851000

Documents

Certificate of Analysis

Protocols & Articles

Articles

LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

The unique combination of column selectivity using Ascentis Express F5 and phospholipid removal using HybridSPE-PLus provides a robust and accurate LC-MS method for accurate and sensitive analysis of...
Craig Aurand, Senior Application Chemist and Hugh Cramer, Associate Scientist
Reporter 32.1
Keywords: Buffers, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reductions, Sample preparations, Separation, Solvents, Vitamins

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

The unique combination of column selectivity using Ascentis Express F5 and phospholipid removal using HybridSPE-PLus provides a robust and accurate LC-MS method for accurate and sensitive analysis of...
Craig Aurand, Hugh Cramer
Reporter US Volume 32.1
Keywords: Buffers, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reductions, Sample preparations, Separation, Solvents, Vitamins

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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