1α-Hydroxyvitamin D3 ≥97.0% (HPLC)

Properties

Related Categories	Metabolic Pathways, Metabolomics, Nutrition Research, Steroid Metabolism, Vitamin D, Vitamin D3, Vitamins More...
assay	≥97.0% (HPLC)
storage temp.	−20°C

Description

Biochem/physiol Actions

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation.¹ Supresses parathyroid hormone secretion by bovine parathyroid cells.²

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Price and Availability

Related Papers

1. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. Shiraishi, A., et al. J. Bone Miner Res. 15, 770-9, (2000)

Documents

Certificate of Analysis

Safety Information

Symbol	GHS06
Signal word	Danger
Hazard statements	H300-H310-H330
Precautionary statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T+
Risk Statements (Europe)	26/27/28
Safety Statements (Europe)	28-36/37-45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	VS2851000