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19176 Sigma

DL-Buthionine-sulfoximine

≥99.0% (TLC)

  • CAS Number 5072-26-4

  • Empirical Formula (Hill Notation) C8H18N2O3S

  • Molecular Weight 222.31

  •  Beilstein Registry Number 2367136

  •  MDL number MFCD00070309

  •  PubChem Substance ID 24851509

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers More...
assay   ≥99.0% (TLC)
solubility   H2O: soluble50 mg/mL, clear to almost clear, colorless
storage temp.   2-8°C

Description

Other Notes

Depletes glutathionine in isolated cells

Application

DL-Buthionine-sulfoximine is suitable for use to:
• examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
• investigate the effect of BSO on development of bovine embryos
• inhibit GSH in several studies
• investigate the effect of GSH synthesis on oocyte maturation
It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Flow Cytometry Instruments
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EK7713435

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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