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21750 Sigma

Capsaicin

from Capsicum sp., ≥50% (HPLC)

Synonym: 8-Methyl-N-vanillyl-trans-6-nonenamide

  • CAS Number 404-86-4

  • Linear Formula (CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)

  • Molecular Weight 305.41

  •  Beilstein Registry Number 2816484

  •  EC Number 206-969-8

  •  MDL number MFCD00017259

  •  PubChem Substance ID 57647941

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Properties

Related Categories Amides, Building Blocks, C8 to C20+, Carbonyl Compounds, Chemical Synthesis,
biological source   from Capsicum sp.
InChI Key   YKPUWZUDDOIDPM-SOFGYWHQSA-N
assay   ≥50% (HPLC)
impurities   ~35% dihydrocapsaicin
mp   62-65 °C(lit.)
  62-65 °C
solubility   H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... CYP1A2(1544), TRPV1(7442)
rat ... Trpv1(83810), Trpv4(66026)

Description

Packaging

1, 5 g in glass bottle

100 mg in glass bottle

Biochem/physiol Actions

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1544PSN1 6.1 / PGIII
WGK Germany 
3
RTECS 
RA8530000
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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