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22049 Sigma

λ-Carrageenan

plant mucopolysaccharide

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Description

Analysis Note

solubility:
10 mg/mL in H2O : clear to very hazy, colorless to faint yellow

General description

non-gelling at 1% in 0.2 M KCl-solution

Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents.

Application

Carrageenans are used to suppress immune response in vivo and in vitro via mechanisms believed to involve selective cytopathic effect on macrophages. Non-gelling λ-carrageenan is used to induce inflammation and inflammatory pain in the rodent hindpaw or air pouch models. More recently carrageenan has been injected directly into the joints of rodents to model arthritic pain and inflammation.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
FI0704000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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