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22640 Sigma

Quinine hemisulfate salt monohydrate

BioReagent, suitable for fluorescence, ≥98.0% (T)

Synonym: Quinine sulfate (2:1) (salt) dihydrate

  • CAS Number 207671-44-1

  • Empirical Formula (Hill Notation) C20H24N2O2 · 0.5H2O4S · H2O

  • Molecular Weight 391.47

  •  Beilstein Registry Number 6113937

  •  MDL number MFCD00150790

  •  PubChem Substance ID 329752330

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Properties

Related Categories Alkaloid, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic,
InChI Key   ZHNFLHYOFXQIOW-LPYZJUEESA-N
product line   BioReagent
assay   ≥98.0% (T)
optical activity   [α]20/D −230±5°, c = 2% in 0.1 M HCl
impurities   ≤10% dihydroquinine sulfate (HPLC)
mp   ~225 °C (dec.)(lit.)
fluorescence   λex 347 nm; λem 448 nm in 0.5 M sulfuric acid
suitability   suitable for fluorescence

Description

Application

Quinine, a natural fluorescence molecule, may be used in a variety of fluorescence based analytical applications as a reagent or reference standard.

Biochem/physiol Actions

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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