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229075 Sigma

1,8-Dihydroxy-3-methylanthraquinone

98%

Synonym: Chrysophanic acid

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Properties

Related Categories Aloe Vera, Building Blocks, C15 to C38, Carbonyl Compounds, Cell Biology,
InChI Key   LQGUBLBATBMXHT-UHFFFAOYSA-N
assay   98%
form   crystalline
color   yellow-orange
solubility   chloroform: soluble1%
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
  viruses
Gene Information   human ... ELA2(1991)

Description

Packaging

1 g in glass bottle

50 mg in glass insert

Application

Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells . It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro .

Biochem/physiol Actions

Anticancer activity for chrysophanic acid is via the EGFR/mTOR mediated signaling transduction pathway . Chrysophanic acid has two hydrophobic positions on the molecule (C-6 and the methyl group attached to C-3) which are responsible for the compound′s activity against poliovirus .

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CB6725000
Protocols & Articles
Peer-Reviewed Papers
15

References

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