Synonym: Chrysophanic acid
|Related Categories||Aloe Vera, Bioactive Small Molecules, Building Blocks, C15 to C38, Carbonyl Compounds,|
|Gene Information||human ... ELA2(1991)|
1 g in glass bottle
50 mg in glass bottle
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.
Anticancer activity for chrysophanic acid is via the EGFR/mTOR mediated signaling transduction pathway 1. Chrysophanic acid has two hydrophobic positions on the molecule (C-6 and the methyl group attached to C-3) which are responsible for the compound′s activity against poliovirus 2.
Certificate of Analysis
|Precautionary statements||P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/38|
|Safety Statements (Europe)||26|
Rapid and efficient purification of chrysophanol in Rheum Palmatum LINN by supercritical fluid extraction coupled with preparative liquid chromatography in tandem. Lo TC, Nian HC, Chiu KH, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 893-894, 101-6, (2012)
Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis. VanMen C, Jang YS, Zhu HM, et al. Phytochem. Anal. 23(4), 359-64, (2012)
Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods. Shi Y, Sun C, Gao B, et al. J. Chromatogr. A 1218(42), 7655-62, (2011)
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract. Fang F, Wang JB, Zhao YL, et al. J. Ethnopharmacol. 137(3), 1492-7, (2011)
Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines. Zhang H, Guo Z, Wu N, et al. Molecules 17(1), 843-50, (2012)
Aldrich MSDS 1, 473:C / Corp MSDS 1 (1), 885:A / FT-IR 2 (2), 2496:A / FT-IR 1 (2), 88:A / RegBook 1 (2), 1689:J / Sax 6, 1074 / Sigma FT-IR 1 (2), 116:C / Structure Index 1, 268:B:4
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