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26740 Sigma

Cholesterol

from lanolin, ≥95.0% (GC)

Synonym: 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol

  • CAS Number 57-88-5

  • Empirical Formula (Hill Notation) C27H46O

  • Molecular Weight 386.65

  •  Beilstein Registry Number 1915888

  •  EC Number 200-353-2

  •  MDL number MFCD00003646

  •  PubChem Substance ID 57648186

  •  eCl@ss 39023139

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Properties

Related Categories Biochemicals and Reagents, Cholesterol and Derivatives, Lipids, Sterol Lipids
biological source   from lanolin
InChI Key   HVYWMOMLDIMFJA-DPAQBDIFSA-N
assay   ≥95.0% (GC)
optical activity   [α]20/D −36±2°, c = 2% in dioxane
bp   360 °C(lit.)
mp   147-149 °C(lit.)
  147-150 °C
density   1.067 g/mL at 25 °C(lit.)
storage temp.   2-8°C
Gene Information   human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)

Description

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Cholesterol is a lipid makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Application

Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

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Laboratory Gloves

The Future of Bioimaging
Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
FZ8400000
Protocols & Articles
Peer-Reviewed Papers
15

References

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