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27555 Sigma

Cloxacillin sodium salt

≥97.0% (HPLC)

  • CAS Number 642-78-4

  • Empirical Formula (Hill Notation) C19H17ClN3NaO5S

  • Molecular Weight 457.86

  •  Beilstein Registry Number 4103180

  •  EC Number 211-390-9

  •  MDL number MFCD00063568

  •  PubChem Substance ID 24856654

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   SCLZRKVZRBKZCR-SLINCCQESA-M
assay   ≥97.0% (HPLC)
impurities   ≤5% water
solubility   H2O: soluble50 mg/mL, clear, colorless
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.

Application

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8750000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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