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27555 Sigma

Cloxacillin sodium salt

≥97.0% (HPLC)

  • CAS Number 642-78-4

  • Empirical Formula (Hill Notation) C19H17ClN3NaO5S

  • Molecular Weight 457.86

  •  Beilstein Registry Number 4103180

  •  EC Number 211-390-9

  •  MDL number MFCD00063568

  •  PubChem Substance ID 57648259

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
biological source   from semisynthetic
InChI Key   SCLZRKVZRBKZCR-SLINCCQESA-M
assay   ≥97.0% (HPLC)
form   powder
impurities   ≤5% water
color   colorless
solubility   H2O: soluble50 mg/mL, clear, colorless
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.

Application

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8750000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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