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27645 Sigma

Demecolcine

≥98.0% (sum of enantiomers, HPLC)

Synonym: N-Deacetyl-N-methylcolchicine

  • CAS Number 477-30-5

  • Empirical Formula (Hill Notation) C21H25NO5

  • Molecular Weight 371.43

  •  Beilstein Registry Number 2822892

  •  EC Number 207-514-6

  •  MDL number MFCD00075459

  •  PubChem Substance ID 329753007

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
grade   USP reference standard
InChI Key   NNJPGOLRFBJNIW-HNNXBMFYSA-N
assay   ≥98.0% (sum of enantiomers, HPLC)
storage temp.   2-8°C

Description

Other Notes

Binds tubulin hence interfering with microtubule-dependent cell function

Same product — same quality — now Sigma brand

Biochem/physiol Actions

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

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Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
GH0800000
Protocols & Articles
Peer-Reviewed Papers
15

References

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replaced by

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Description

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D7385 Demecolcine, ≥98% (HPLC)

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