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27655 Sigma

Colistin sodium methanesulfonate

from Bacillus colistinus

Synonym: Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
biological source   from Bacillus colistinus
material   white to faintly beige
InChI Key   WSDSONZFNWDYGZ-BKFDUBCBSA-I
form   powder
mol wt   mol wt 1759.9 g/mol
ign. residue   ~20%
loss   ≤1.5% loss on drying
pH   6-8 (10 mg/mL in H2O)
solubility   H2O: soluble10 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect .

Application

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients .

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
GH1650000
Protocols & Articles
Peer-Reviewed Papers
15

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