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27840 Sigma

Corticosterone

≥98.5% (HPLC)

Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

  • CAS Number 50-22-6

  • Empirical Formula (Hill Notation) C21H30O4

  • Molecular Weight 346.46

  •  Beilstein Registry Number 2339601

  •  EC Number 200-019-6

  •  MDL number MFCD00037715

  •  PubChem Substance ID 57648276

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Properties

Related Categories Biochemicals and Reagents, Lipids, Steroids (C21) and Derivatives, Sterol Lipids
InChI Key   OMFXVFTZEKFJBZ-HJTSIMOOSA-N
assay   ≥98.5% (HPLC)
optical activity   [α]20/D +223±3°, c = 1% in ethanol
mp   179-183 °C(lit.)
  179-183 °C
Gene Information   human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Corticosterone is soluble in chloroform and ethanol.

Application

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Biochem/physiol Actions

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

General description

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GM7650000
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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