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27840 Sigma

Corticosterone

≥98.5% (HPLC)

Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

  • CAS Number 50-22-6

  • Empirical Formula (Hill Notation) C21H30O4

  • Molecular Weight 346.46

  •  Beilstein Registry Number 2339601

  •  EC Number 200-019-6

  •  MDL number MFCD00037715

  •  PubChem Substance ID 57648276

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Properties

Related Categories Biochemicals and Reagents, Lipids, Steroids (C21) and Derivatives, Sterol Lipids
InChI Key   OMFXVFTZEKFJBZ-HJTSIMOOSA-N
assay   ≥98.5% (HPLC)
optical activity   [α]20/D +223±3°, c = 1% in ethanol
mp   179-183 °C(lit.)
  179-183 °C
Gene Information   human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Corticosterone is soluble in chloroform and ethanol.

Application

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Biochem/physiol Actions

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

General description

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GM7650000
Protocols & Articles

Articles

HPLC Analysis of Glucocorticoids on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Glucocorticoids on Ascentis® C8
Keywords: Chromatography, Clinical, High performance liquid chromatography, Hormones

HPLC Analysis of Steroids on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography

LC/MS/MS Analysis of Steroid Hormones in Plasma on Ascentis® Express C18 after Sample Prep using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Steroid Hormones in Plasma on Ascentis® Express C18 after Sample Prep using HybridSPE®-Phospholipid
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Precipitation, Separation, Solid phase extractions, Solvents

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

UHPLC Analysis of Corticosteroids on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Corticosteroids on Titan™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

UHPLC/MS Analysis of Steroids on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Steroids on Titan™ C18
Keywords: Chromatography, Mass spectrometry, Pharmaceutical

Peer-Reviewed Papers
15

References

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