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28007 Sigma

Crotonoyl coenzyme A trilithium salt

~90% (HPLC)

Synonym: trans-2-Butenoyl coenzyme A trilithium salt

  • Empirical Formula (Hill Notation) C25H37Li3N7O17P3S

  • Molecular Weight 853.41

  •  MDL number MFCD00151226

  •  PubChem Substance ID 24856925

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Coenzyme A and Derivatives, Fatty Acid Metabolism, Metabolic Pathways,
InChI Key   LUYQFKSDLNQLEG-OUWZIDFPSA-K
assay   ~90% (HPLC)
impurities   ≤10% water
solubility   H2O: soluble50 mg/mL, clear, colorless
storage temp.   −20°C

Description

Other Notes

Oxidation-reduction of general acyl-CoA dehydrogenase by the butyryl-CoA/crotonyl-CoA couple; Purification of rat liver microsomal trans-2-enoyl-CoA reductase

Application

Crotonoyl coenzyme A (Crotonoyl -CoA) may be used in anti-tubercular and anti-malarial drug research as a substrate to help identify and characterized enzymes such as Plasmodium falciparum enoyl-ACP reductase (PfENR) and other enoyl-CoA reductases that may be effective drug targets. Crotonoyl -CoA may be used as a substrate analogue for kinetic studies on ß-hydroxyacyl-acyl carrier protein (ACP) dehydratase (FabZ).

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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