|Related Categories||Bioactive Small Molecules, Cell Biology, Flavonoids, Flavonols, and Flavanols, G, Nutrition Research,|
human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)|
rat ... Adora1(29290), Adora2a(25369)
25, 100 mg in glass bottle
Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity induced by molecules such as benzo[a]pyrene (B(a)P) and oxidation. Galangin may be used to study the expression of the cytochrome P450 isozyme CYP1A1 and to inhibit CYP1A1 activity. Autophagy inducer.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 282200.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-37/39|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Li S, Wu C, Zhu L, et al. Molecules 17(11), 13403-23, (2012)
Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. Jung CH, Jang SJ, Ahn J, et al. J. Med. Food 15(11), 959-67, (2012)
The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. Huh JE, Jung IT, Choi J, et al. Eur. J. Pharmacol. 698(1-3), 57-66, (2013)
Influence of oxidative stress on inducing micturition dysfunction following chronic infravesical obstruction and the protective role of an antioxidant diet - association of in vivo and in vitro studies in rats. Bisogni S, Ferreira FT, Amstalden Neto A, et al. Int. Braz J Urol 38(4), 552-60, (2012)
SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles. Zhang W, Bai X, Wang Y, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 92, 234-7, (2012)
Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. Eumkeb G, Siriwong S, Phitaktim S, et al. J. Appl. Microbiol. 112(1), 55-64, (2012)
Galangin suppresses the proliferation of β-catenin response transcription-positive cancer cells by promoting adenomatous polyposis coli/Axin/glycogen synthase kinase-3β-independent β-catenin degradation. Gwak J, Oh J, Cho M, et al. Mol. Pharmacol. 79(6), 1014-22, (2011)
In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment. Lei Y, Chen J, Zhang W, et al. Food Chem. 135(4), 2702-7, (2012)
The bioflavonoid galangin suppresses the growth of ehrlich ascites carcinoma in Swiss Albino mice: a molecular insight. Jaiswal JV, Wadegaonkar PA, and Hajare SW Appl. Biochem. Biotechnol. 167(5), 1325-39, (2012)
Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. Kim DA, Jeon YK, and Nam MJ Food Chem. Toxicol. 50(3-4), 684-8, (2012)
Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat. Barson JR, Chang GQ, Poon K, et al. Neuroscience 193, 10-20, (2011)
Corp MSDS 1 (1), 1760:B / RegBook 1 (2), 1695:I / Sax 6, 1469 / Structure Index 1, 269:A:4
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