EMAIL THIS PAGE TO A FRIEND

282200 Sigma

Galangin

autophagy inducing flavonoid

Synonym: 3,5,7-Trihydroxyflavone

Purchase

Properties

Related Categories Cell Biology, Flavonoids, Flavonols, and Flavanols, Nutrition Research, Phytochemicals by Chemical Classification
mp   214-215 °C(lit.)
Gene Information   human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)

Description

Packaging

25, 100 mg in glass bottle

Biochem/physiol Actions

Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity induced by molecules such as benzo[a]pyrene (B(a)P) and oxidation. Galangin may be used to study the expression of the cytochrome P450 isozyme CYP1A1 and to inhibit CYP1A1 activity. Autophagy inducer.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 282200.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Customers Also Viewed

Chrysin
C80105Chrysin

97%

Chrysin
95082Chrysin

analytical standard

Kaempferide

analytical standard

Pinobanksin

≥95% (HPLC)

Pinocembrin

analytical standard, 95% (TLC), solid

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-37/39
WGK Germany 
3
RTECS 
LK9275500

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers

References

Set your institution to view full text papers.

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Ciolino HP, Yeh GC. Br. J. Cancer 79, 1340-1346, (1999)

Loading...


Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Zheng, L.T., et al. Int. Immunopharmacol. 8, 484-94, (2008)

Loading...


Effect of galangin supplementation on oxidative damage and inflammatory changes in fructose-fed rat liver. Sivakumar AS, Anuradha CV. Chem. Biol. Interact. 193, 141-148, (2011)

Loading...


Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. Kozics K, Valovicova Z, Slamenova D. Neoplasma 58, 516-524, (2011)

Loading...


Potent modification of inducible CYP1A1 expression by flavonoids. Chatuphonprasert W, Kondo S, et al. Biol. Pharm. Bull. 33, 1698-1703, (2010)

Loading...


Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway. Wang Y, Wu J, Lin B, et al. Toxicology 326, 9-17, (2014)

Loading...


The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. Huh JE, Jung IT, Choi J, et al. Eur. J. Pharmacol. 698(1-3), 57-66, (2013)

Loading...


Current pharmacological and phytochemical studies of the plant Alpinia galanga. Kaushik D, Yadav J, Kaushik P, et al. Zhong Xi Yi Jie He Xue Bao 9(10), 1061-5, (2011)

Loading...


Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS. Liu X, Han Y, Peng K, et al. Adv. Dent. Res. 23(1), 56-60, (2011)

Loading...


Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate. Heo MY, Sohn SJ, and Au WW Mutat. Res. 488(2), 135-50, (2001)

Loading...


Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. Kim DA, Jeon YK, and Nam MJ Food Chem. Toxicol. 50(3-4), 684-8, (2012)

Loading...


¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts. Bertelli D, Papotti G, Bortolotti L, et al. Phytochem. Anal. 23(3), 260-6, (2012)

Loading...


Galangin suppresses the proliferation of β-catenin response transcription-positive cancer cells by promoting adenomatous polyposis coli/Axin/glycogen synthase kinase-3β-independent β-catenin degradation. Gwak J, Oh J, Cho M, et al. Mol. Pharmacol. 79(6), 1014-22, (2011)

Loading...


In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment. Lei Y, Chen J, Zhang W, et al. Food Chem. 135(4), 2702-7, (2012)

Loading...


Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae). Ludwiczuk, A., et al. Phytomedicine 18, 491-498, (2011)

Loading...


Galangin inhibits tumor growth and metastasis of B16F10 melanoma. Zhang W, Tang B, Huang Q, et al. J. Cell. Biochem. 114(1), 152-61, (2013)

Loading...


Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. Resende FA, Vilegas W, Dos Santos LC, et al. Molecules 17(5), 5255-68, (2012)

Loading...


Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. Eumkeb G, Siriwong S, Phitaktim S, et al. J. Appl. Microbiol. 112(1), 55-64, (2012)

Loading...


Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. Ha TK, Kim ME, Yoon JH, et al. Exp. Biol. Med. (Maywood.) 238(9), 1047-54, (2013)

Loading...


The photodegradation of quercetin: relation to oxidation. Dall'Acqua S, Miolo G, Innocenti G, et al. Molecules 17(8), 8898-907, (2012)

Loading...


Galangin induces autophagy through upregulation of p53 in HepG2 cells. Wen M, Wu J, Luo H, et al. Pharmacology 89(5-6), 247-55, (2012)

Loading...


SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles. Zhang W, Bai X, Wang Y, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 92, 234-7, (2012)

Loading...


Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. Satué M, Arriero Mdel M, Monjo M, et al. Biochem. Pharmacol. 86(10), 1476-86, (2013)

Loading...


Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. Wang X, Gong G, Yang W, et al. Environ. Toxicol. Pharmacol. 36(2), 288-95, (2013)

Loading...


Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway. Zhang HT, Wu J, Wen M, et al. J. Asian Nat. Prod. Res. 14(7), 626-33, (2012)

Loading...


Analysis of serum metabolites for the discovery of amino acid biomarkers and the effect of galangin on cerebral ischemia. Gao J, Yang H, Chen J, et al. Mol. Biosyst. 9(9), 2311-21, (2013)

Loading...


Influence of dietary flavonoids on the glycation of plasma proteins. Liu L, Xie Y, Song Z, et al. Mol. Biosyst. 8(8), 2183-7, (2012)

Loading...


Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. Jung CH, Jang SJ, Ahn J, et al. J. Med. Food 15(11), 959-67, (2012)

Loading...


Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat. Barson JR, Chang GQ, Poon K, et al. Neuroscience 193, 10-20, (2011)

Loading...


The bioflavonoid galangin suppresses the growth of ehrlich ascites carcinoma in Swiss Albino mice: a molecular insight. Jaiswal JV, Wadegaonkar PA, and Hajare SW Appl. Biochem. Biotechnol. 167(5), 1325-39, (2012)

Loading...


By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Li S, Wu C, Zhu L, et al. Molecules 17(11), 13403-23, (2012)

Loading...


Anticomplement and antimicrobial activities of flavonoids from Entada phaseoloides. Li K, Xing S, Wang M, et al. Nat. Prod. Commun. 7(7), 867-71, (2012)

Loading...


Inhibition of Klebsiella pneumoniae DnaB helicase by the flavonol galangin. Chen CC and Huang CY Protein J. 30(1), 59-65, (2011)

Loading...


Dose-dependent effect of galangin on fructose-mediated insulin resistance and oxidative events in rat kidney. Sivakumar AS, Viswanathan P, and Anuradha CV Redox Rep. 15(5), 224-32, (2010)

Loading...


Influence of oxidative stress on inducing micturition dysfunction following chronic infravesical obstruction and the protective role of an antioxidant diet - association of in vivo and in vitro studies in rats. Bisogni S, Ferreira FT, Amstalden Neto A, et al. Int. Braz J Urol 38(4), 552-60, (2012)

Loading...


Merck 14,4339

Beil. 18,V,4,567

Corp MSDS 1 (1), 1760:B / RegBook 1 (2), 1695:I / Sax 6, 1469 / Structure Index 1, 269:A:4

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?