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28266 Sigma

Levofloxacin

≥98.0% (HPLC)

Synonym: (−)-Ofloxacin

  • CAS Number 100986-85-4

  • Empirical Formula (Hill Notation) C18H20FN3O4

  • Molecular Weight 361.37

  •  Beilstein Registry Number 7327015

  •  MDL number MFCD00865049

  •  PubChem Substance ID 57648297

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents
InChI Key   GSDSWSVVBLHKDQ-JTQLQIEISA-N
assay   ≥98.0% (HPLC)
solubility   chloroform: soluble10 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
Gene Information   human ... KCNH1(3756)

Description

Application

Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic , antibiotic resistance , and resistance prevention studies. Antibiotic against bacterial respiratory tract infections.

Biochem/physiol Actions

Levofloxacin is active against Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase (type II topoisomerase) and topoisomerase IV, thereby inhibiting cell division.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 28266.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UU8815550
Protocols & Articles

Articles

Inhibition of Nucleic Acid Synthesis by Antibiotics

Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication. DNA gyra...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antitumor agents, Cancer, DNA replication

Peer-Reviewed Papers
15

References

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