Levofloxacin

Papers

1. Steady-State Plasma and Intrapulmonary Concentrations of Levofloxacin and Ciprofloxacin in Healthy Adult Subjects. Mark H. Gotfried, Larry H. Danziger, et al. Chest 119, 1114-1122, (2001)

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2. Relationships among Ciprofloxacin, Gatifloxacin, Levofloxacin, and Norfloxacin MICs for Fluoroquinolone-Resistant Escherichia coli Clinical Isolates. Lauren Becnel Boyd, Merry J. Maynard, et al. Antimicrob. Agents Chemother. 53, 229-234, (2009)

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3. In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae. Arnold Louie, David L. Brown, et al. Antimicrob. Agents Chemother. 51, 3988-4000, (2007)

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4. The inhibitory effects of fluoroquinolones on L-carnitine transport in placental cell line BeWo. Hirano T, Yasuda S, Osaka Y Int. J. Pharm. 351, 113-118, (2008)

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5. Antibiotic against bacterial respiratory tract infections. G.G. Zhanel et al. Drugs 62, 13, (2002)

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6. Levofloxacin: an updated review of its use in the treatment of bacterial infections. M. Hurst et al. Drugs 62, 2127, (2002)

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Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. Wiles, J. A. et al. J. Med. Chem. 50, 199-210, (2007)

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A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. Noel J de Souza et al J. Med. Chem. 48, 5232-42, (2005)

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Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives. T Matthew Hansen et al Bioorg. Med. Chem. Lett. 15, 2716-9, (2005)

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A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Motoi Tobita et al Bioorg. Med. Chem. Lett. 15, 2886-90, (2005)

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3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. Edmund L Ellsworth et al J. Med. Chem. 49, 6435-8, (2006)

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The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents. Sean T Murphy et al Bioorg. Med. Chem. Lett. 17, 2150-5, (2007)

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Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. Jian Lv et al Bioorg. Med. Chem. Lett. 17, 4102-6, (2007)

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Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane. Yoshifumi Ikee et al Bioorg. Med. Chem. Lett. 17, 942-5, (2007)

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Synthesis and structure-activity relationship of 7-(substituted)-aminomethyl-4-quinolone-3-carboxylic acid derivatives. Zhenfa Zhang et al Bioorg. Med. Chem. 15, 7274-80, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring. Alireza Foroumadi et al Eur. J. Med. Chem. 42, 985-92, (2007)

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Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. Radosław Izdebski et al Antimicrob. Agents Chemother. 51, 1155-63, (2007)

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In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups. Michael D Huband et al Antimicrob. Agents Chemother. 51, 1191-201, (2007)

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In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. Michael J Pucci et al Antimicrob. Agents Chemother. 51, 1259-67, (2007)

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Fluoroquinolone resistance in Streptococcus pneumoniae: area under the concentration-time curve/MIC ratio and resistance development with gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin. Kerry L LaPlante et al Antimicrob. Agents Chemother. 51, 1315-20, (2007)

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Antistaphylococcal activity of DX-619 alone and in combination with vancomycin, teicoplanin, and linezolid assessed by time-kill synergy testing. Kim Credito et al Antimicrob. Agents Chemother. 51, 1508-11, (2007)

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In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci. Seong Geun Hong et al Antimicrob. Agents Chemother. 51, 1512-4, (2007)

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First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. Mariana Castanheira et al Antimicrob. Agents Chemother. 51, 1527-9, (2007)

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Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability. María Pérez-Vázquez et al Antimicrob. Agents Chemother. 51, 1566-9, (2007)

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Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones. Stéphanie Matrat et al Antimicrob. Agents Chemother. 51, 1643-8, (2007)

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Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Mario Tumbarello et al Antimicrob. Agents Chemother. 51, 1987-94, (2007)

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Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Daniel R Gentry et al Antimicrob. Agents Chemother. 51, 2048-52, (2007)

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Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. Andrea Endimiani et al Antimicrob. Agents Chemother. 51, 2211-4, (2007)

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Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. J M Rodríguez-Martínez et al Antimicrob. Agents Chemother. 51, 2236-9, (2007)

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Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. A Stucki et al Antimicrob. Agents Chemother. 51, 2249-52, (2007)

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Activity of Garenoxacin against Macrolide-Susceptible and -Resistant Mycoplasma pneumoniae. Tsutomu Yamazaki et al Antimicrob. Agents Chemother. 51, 2278-9, (2007)

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High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. Linda M Weigel et al Antimicrob. Agents Chemother. 51, 231-8, (2007)

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Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Bruno Périchon et al Antimicrob. Agents Chemother. 51, 2464-9, (2007)

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Efficacy of a novel rifamycin derivative, ABI-0043, against Staphylococcus aureus in an experimental model of foreign-body infection. Andrej Trampuz et al Antimicrob. Agents Chemother. 51, 2540-5, (2007)

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In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Jong Hwa Yum et al Antimicrob. Agents Chemother. 51, 2591-3, (2007)

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Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 51, 2611-4, (2007)

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Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model. Matthew E Griffith et al Antimicrob. Agents Chemother. 51, 2615-7, (2007)

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Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. Jeong Hwan Shin et al Antimicrob. Agents Chemother. 51, 2625-7, (2007)

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Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy. Arnold Louie et al Antimicrob. Agents Chemother. 51, 2661-7, (2007)

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Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. Daniel A Adams et al Antimicrob. Agents Chemother. 51, 2674-8, (2007)

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Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae. Margaret Ip et al Antimicrob. Agents Chemother. 51, 2690-700, (2007)

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In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004. David W Hecht et al Antimicrob. Agents Chemother. 51, 2716-9, (2007)

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Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis. Carolyn V Gould et al Antimicrob. Agents Chemother. 51, 3225-9, (2007)

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Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. Laura Calatayud et al Antimicrob. Agents Chemother. 51, 3240-6, (2007)

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Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones. Stéphanie Arsène et al Antimicrob. Agents Chemother. 51, 3254-8, (2007)

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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Kunikazu Yamane et al Antimicrob. Agents Chemother. 51, 3354-60, (2007)

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In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. W T M Jansen et al Antimicrob. Agents Chemother. 51, 3420-4, (2007)

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Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model. Lisa A Kroeger et al Antimicrob. Agents Chemother. 51, 3431-3, (2007)

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Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? Dewan Sakhawat Billal et al Antimicrob. Agents Chemother. 51, 3463-4, (2007)

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In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. Barbara D Foleno et al Antimicrob. Agents Chemother. 51, 361-5, (2007)

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Development of resistance in wild-type and hypermutable Pseudomonas aeruginosa strains exposed to clinical pharmacokinetic profiles of meropenem and ceftazidime simulated in vitro. Beate Henrichfreise et al Antimicrob. Agents Chemother. 51, 3642-9, (2007)

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Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. Hyunjoo Pai et al Antimicrob. Agents Chemother. 51, 366-8, (2007)

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Pharmacodynamic assessment based on mutant prevention concentrations of fluoroquinolones to prevent the emergence of resistant mutants of Streptococcus pneumoniae. Tomoyuki Homma et al Antimicrob. Agents Chemother. 51, 3810-5, (2007)

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Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. Muneki Hotomi et al Antimicrob. Agents Chemother. 51, 3969-76, (2007)

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Comparison of beta-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized Veterans Affairs patients with community-acquired pneumonia. Thomas P Lodise et al Antimicrob. Agents Chemother. 51, 3977-82, (2007)

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Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Hui Wang et al Antimicrob. Agents Chemother. 51, 4022-8, (2007)

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In vitro and in vivo activities of novel fluoroquinolones alone and in combination with clarithromycin against clinically isolated Mycobacterium avium complex strains in Japan. Yoshihisa Kohno et al Antimicrob. Agents Chemother. 51, 4071-6, (2007)

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Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. Xiaogang Xu et al Antimicrob. Agents Chemother. 51, 4105-10, (2007)

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Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Daniel E Rozen et al Antimicrob. Agents Chemother. 51, 412-6, (2007)

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Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. Tatiana Bogdanovich et al Antimicrob. Agents Chemother. 51, 4191-5, (2007)

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Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Catherine L Clark et al Antimicrob. Agents Chemother. 51, 4196-201, (2007)

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Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 51, 4205-8, (2007)

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Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. John D Szumowski et al Antimicrob. Agents Chemother. 51, 423-8, (2007)

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National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. Ian A Critchley et al Antimicrob. Agents Chemother. 51, 4382-9, (2007)

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Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. María Paula Quiroga et al Antimicrob. Agents Chemother. 51, 4466-70, (2007)

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Antimicrobial susceptibilities and clinical sources of Dialister species. F Morio et al Antimicrob. Agents Chemother. 51, 4498-501, (2007)

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Diversity of ampicillin resistance genes and antimicrobial susceptibility patterns in Haemophilus influenzae strains isolated in Korea. In-Suk Kim et al Antimicrob. Agents Chemother. 51, 453-60, (2007)

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Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Sheng Chen et al Antimicrob. Agents Chemother. 51, 535-42, (2007)

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Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. Ying Ying Chan et al Antimicrob. Agents Chemother. 51, 623-30, (2007)

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Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. Klaudia Kosowska-Shick et al Antimicrob. Agents Chemother. 51, 770-3, (2007)

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First characterization of fluoroquinolone resistance in Streptococcus suis. Jose Antonio Escudero et al Antimicrob. Agents Chemother. 51, 777-82, (2007)

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Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Céline Vidaillac et al Antimicrob. Agents Chemother. 51, 831-8, (2007)

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Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. Yoshimi Hirokawa et al J. Med. Chem. 51, 1991-4, (2008)

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Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent. Yoshikazu Asahina et al J. Med. Chem. 51, 3238-49, (2008)

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Support vector machines classification of hERG liabilities based on atom types. Lei Jia et al Bioorg. Med. Chem. 16, 6252-60, (2008)

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Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. Roseanne A Ressner et al Antimicrob. Agents Chemother. 52, 1147-9, (2008)

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Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. Helio S Sader et al Antimicrob. Agents Chemother. 52, 1153-5, (2008)

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Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. George G Zhanel et al Antimicrob. Agents Chemother. 52, 1430-7, (2008)

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Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes. Carlos Salas et al Antimicrob. Agents Chemother. 52, 1503-5, (2008)

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Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. Kunikazu Yamane et al Antimicrob. Agents Chemother. 52, 1564-6, (2008)

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In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. Laura Lawrence et al Antimicrob. Agents Chemother. 52, 1653-62, (2008)

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Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. Patricia J Baudry et al Antimicrob. Agents Chemother. 52, 1846-9, (2008)

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Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Hsiu-Mei Wu et al Antimicrob. Agents Chemother. 52, 1888-90, (2008)

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Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). Elia Gómez G de la Pedrosa et al Antimicrob. Agents Chemother. 52, 1964-9, (2008)

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Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. Yu-Chia Hsieh et al Antimicrob. Agents Chemother. 52, 2266-9, (2008)

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In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. Sandra K Urich et al Antimicrob. Agents Chemother. 52, 2276-8, (2008)

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Antistreptococcal activity of AR-709 compared to that of other agents. Kathy Smith et al Antimicrob. Agents Chemother. 52, 2279-82, (2008)

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In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Gregory T Robertson et al Antimicrob. Agents Chemother. 52, 2313-23, (2008)

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Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States. Deborah C Draghi et al Antimicrob. Agents Chemother. 52, 2383-8, (2008)

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Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. Somvadee Laohavaleeson et al Antimicrob. Agents Chemother. 52, 2389-94, (2008)

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Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. Ian A Critchley et al Antimicrob. Agents Chemother. 52, 2639-43, (2008)

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In vitro activity of telavancin against resistant gram-positive bacteria. Kevin M Krause et al Antimicrob. Agents Chemother. 52, 2647-52, (2008)

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In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. Gregory G Stone et al Antimicrob. Agents Chemother. 52, 2663-6, (2008)

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Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. Andrea Endimiani et al Antimicrob. Agents Chemother. 52, 2680-2, (2008)

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Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. Roseanne A Ressner et al Antimicrob. Agents Chemother. 52, 2750-4, (2008)

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Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Tetsufumi Koga et al Antimicrob. Agents Chemother. 52, 2849-54, (2008)

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In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy. Ellen S Moland et al Antimicrob. Agents Chemother. 52, 2940-2, (2008)

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Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates. Inna Chmelnitsky et al Antimicrob. Agents Chemother. 52, 2962-5, (2008)

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Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcus aureus strains. Saichi Hoshi et al Antimicrob. Agents Chemother. 52, 2970-3, (2008)

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Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. Jian-Hua Liu et al Antimicrob. Agents Chemother. 52, 2992-3, (2008)

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Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. Simona Bratu et al Antimicrob. Agents Chemother. 52, 2999-3005, (2008)

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Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. Chia-Ying Liu et al Antimicrob. Agents Chemother. 52, 3161-8, (2008)

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Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Mario Tumbarello et al Antimicrob. Agents Chemother. 52, 3244-52, (2008)

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In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. Yigong Ge et al Antimicrob. Agents Chemother. 52, 3398-407, (2008)

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In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. Karen M Amsler et al Antimicrob. Agents Chemother. 52, 3418-23, (2008)

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Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia. Carlo McCalla et al Antimicrob. Agents Chemother. 52, 3441-3, (2008)

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Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. Miyuki Morozumi et al Antimicrob. Agents Chemother. 52, 348-50, (2008)

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Antagonistic effect of rifampin on the efficacy of high-dose levofloxacin in staphylococcal experimental foreign-body infection. O Murillo et al Antimicrob. Agents Chemother. 52, 3681-6, (2008)

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Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. Ken B Waites et al Antimicrob. Agents Chemother. 52, 3776-8, (2008)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Kenichiro Shimizu et al Antimicrob. Agents Chemother. 52, 3823-5, (2008)

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First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. Gian Maria Rossolini et al Antimicrob. Agents Chemother. 52, 4023-9, (2008)

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Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. S Page et al Antimicrob. Agents Chemother. 52, 4155-8, (2008)

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In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. R Fernández-Roblas et al Antimicrob. Agents Chemother. 52, 4184-6, (2008)

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In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. Asunción Fenoll et al Antimicrob. Agents Chemother. 52, 4209-10, (2008)

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Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. Noriyuki Nagano et al Antimicrob. Agents Chemother. 52, 4258-67, (2008)

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High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Hong Yang et al Antimicrob. Agents Chemother. 52, 4268-73, (2008)

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Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Daniel R Gentry et al Antimicrob. Agents Chemother. 52, 4507-9, (2008)

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Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. Wenming Zhu et al Antimicrob. Agents Chemother. 52, 452-7, (2008)

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AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Laurence Damier-Piolle et al Antimicrob. Agents Chemother. 52, 557-62, (2008)

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In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. Catherine Clark et al Antimicrob. Agents Chemother. 52, 77-84, (2008)

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RmtC 16S rRNA methyltransferase in Australia. Zhiyong Zong et al Antimicrob. Agents Chemother. 52, 794-5, (2008)

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Fitness of Streptococcus pneumoniae fluoroquinolone-resistant strains with topoisomerase IV recombinant genes. Luz Balsalobre et al Antimicrob. Agents Chemother. 52, 822-30, (2008)

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Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis. Charles A Peloquin et al Antimicrob. Agents Chemother. 52, 852-7, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. Laurence Miguet et al J. Med. Chem. 52, 5926-36, (2009)

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Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Markus Fridén et al J. Med. Chem. 52, 6233-43, (2009)

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7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. Joëlle Azéma et al Bioorg. Med. Chem. 17, 5396-407, (2009)

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Interaction of drug based binuclear mixed-ligand complexes with DNA. Mohan N Patel et al Bioorg. Med. Chem. 17, 5648-55, (2009)

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Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Rie Miyauchi et al Bioorg. Med. Chem. 17, 6879-89, (2009)

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Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl beta-aldehyde ketone derivatives. Jinbing Liu et al Eur. J. Med. Chem. 44, 1737-44, (2009)

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Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives. Yun Chai et al Eur. J. Med. Chem. 44, 4063-9, (2009)

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Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. Qin Yan et al Eur. J. Med. Chem. 44, 4235-43, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. Daniela Baldoni et al Antimicrob. Agents Chemother. 53, 1142-8, (2009)

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Effect of DNase and antibiotics on biofilm characteristics. George V Tetz et al Antimicrob. Agents Chemother. 53, 1204-9, (2009)

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Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. Longzhu Cui et al Antimicrob. Agents Chemother. 53, 1231-4, (2009)

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Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Tetsufumi Koga et al Antimicrob. Agents Chemother. 53, 1238-41, (2009)

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Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 53, 1260-3, (2009)

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In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. Steven D Brown et al Antimicrob. Agents Chemother. 53, 1271-4, (2009)

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Urinary bactericidal activity of Doripenem versus that of levofloxacin in patients with complicated urinary tract infections or pyelonephritis. Florian M E Wagenlehner et al Antimicrob. Agents Chemother. 53, 1567-73, (2009)

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Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. Hidekazu Suzuki et al Antimicrob. Agents Chemother. 53, 1720-1, (2009)

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New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Minghua Wang et al Antimicrob. Agents Chemother. 53, 1892-7, (2009)

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Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. Ken B Waites et al Antimicrob. Agents Chemother. 53, 2139-41, (2009)

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Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. Yang Liu et al Antimicrob. Agents Chemother. 53, 2160-2, (2009)

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Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. Helio S Sader et al Antimicrob. Agents Chemother. 53, 2171-5, (2009)

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Comparative antipneumococcal activities of sulopenem and other drugs. Klaudia Kosowska-Shick et al Antimicrob. Agents Chemother. 53, 2239-47, (2009)

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Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 53, 235-41, (2009)

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In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Céline Vidaillac et al Antimicrob. Agents Chemother. 53, 2360-6, (2009)

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Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro. Patrizia Spigaglia et al Antimicrob. Agents Chemother. 53, 2463-8, (2009)

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High prevalence of qnr genes in commensal enterobacteria from healthy children in Peru and Bolivia. Lucia Pallecchi et al Antimicrob. Agents Chemother. 53, 2632-5, (2009)

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Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. Somay Yamagata Murayama et al Antimicrob. Agents Chemother. 53, 2650-3, (2009)

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KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. Jason W Bennett et al Antimicrob. Agents Chemother. 53, 292-4, (2009)

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Sitafloxacin activity against Helicobacter pylori isolates, including those with gyrA mutations. Kazunari Murakami et al Antimicrob. Agents Chemother. 53, 3097-9, (2009)

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First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. Marina Cerquetti et al Antimicrob. Agents Chemother. 53, 3112-4, (2009)

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Emergence of quinolone-resistant Bordetella pertussis in Japan. Masayuki Ohtsuka et al Antimicrob. Agents Chemother. 53, 3147-9, (2009)

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Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. Constança Pomba et al Antimicrob. Agents Chemother. 53, 327-8, (2009)

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Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. Stephen P Hawser et al Antimicrob. Agents Chemother. 53, 3280-4, (2009)

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Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. Caroline Wehmeier et al Antimicrob. Agents Chemother. 53, 329-30, (2009)

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Pharmacodynamics of levofloxacin in a murine pneumonia model of Pseudomonas aeruginosa infection: determination of epithelial lining fluid targets. Arnold Louie et al Antimicrob. Agents Chemother. 53, 3325-30, (2009)

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. James A Karlowsky et al Antimicrob. Agents Chemother. 53, 3544-8, (2009)

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Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. Wolfgang Haas et al Antimicrob. Agents Chemother. 53, 3552-60, (2009)

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In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms. Kazuko Yamamoto et al Antimicrob. Agents Chemother. 53, 3572-5, (2009)

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Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. Wenjia Sun et al Antimicrob. Agents Chemother. 53, 3642-9, (2009)

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Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem β-lactamase inhibitor BLI-489. Petersen, P.J., et al. Antimicrob. Agents Chemother. 53, 370-384, (2009)

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Intravenous doripenem at 500 milligrams versus levofloxacin at 250 milligrams, with an option to switch to oral therapy, for treatment of complicated lower urinary tract infection and pyelonephritis. K G Naber et al Antimicrob. Agents Chemother. 53, 3782-92, (2009)

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Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. Marianne Gunell et al Antimicrob. Agents Chemother. 53, 3832-6, (2009)

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Efficacy of aerosol MP-376, a levofloxacin inhalation solution, in models of mouse lung infection due to Pseudomonas aeruginosa. Mojgan Sabet et al Antimicrob. Agents Chemother. 53, 3923-8, (2009)

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Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. Katie Saxton et al Antimicrob. Agents Chemother. 53, 412-20, (2009)

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In vitro activities of panduratin A against clinical Staphylococcus strains. Yaya Rukayadi et al Antimicrob. Agents Chemother. 53, 4529-32, (2009)

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Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. C Hal Jones et al Antimicrob. Agents Chemother. 53, 465-75, (2009)

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Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. Francis F Arhin et al Antimicrob. Agents Chemother. 53, 4762-71, (2009)

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In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates. Heather J Adam et al Antimicrob. Agents Chemother. 53, 4915-20, (2009)

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Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. Ryoichi Hamasuna et al Antimicrob. Agents Chemother. 53, 4938-9, (2009)

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Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. Pornpan Koomanachai et al Antimicrob. Agents Chemother. 53, 5060-3, (2009)

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High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Junying Ma et al Antimicrob. Agents Chemother. 53, 519-24, (2009)

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Susceptibilities of 23 Desulfovibrio isolates from humans. Ken-ichi Nakao et al Antimicrob. Agents Chemother. 53, 5308-11, (2009)

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In vitro activity of a new quinoline derivative, ER-2, against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis. Shilpakala Sainath Rao et al Antimicrob. Agents Chemother. 53, 5317-8, (2009)

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Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains. Kim Credito et al Antimicrob. Agents Chemother. 53, 814-7, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Synthesis and in vitro antibacterial activity of novel fluoroquinolone derivatives containing substituted piperidines. Yun Chai et al Bioorg. Med. Chem. Lett. 20, 5195-8, (2010)

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Synthesis and biological evaluation of tetracyclic fluoroquinolones as antibacterial and anticancer agents. Salah A Al-Trawneh et al Bioorg. Med. Chem. 18, 5873-84, (2010)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: improved synthesis and in vitro evaluation. Alexander Korolyov et al Bioorg. Med. Chem. 18, 8537-48, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities M. D. Aytemir and B. Oezcelik, Eur. J. Med. Chem. 45, 4089-4095, (2010)

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Synthesis and in vitro antibacterial activity of fluoroquinolone derivatives containing 3-(N'-alkoxycarbamimidoyl)-4-(alkoxyimino) pyrrolidines. Qiang Guo et al Eur. J. Med. Chem. 45, 5498-506, (2010)

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Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety. Nuray Ulusoy Güzeldemirci et al Eur. J. Med. Chem. 45, 63-8, (2010)

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Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. M Indriati Hood et al Antimicrob. Agents Chemother. 54, 1029-41, (2010)

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Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. Jared L Crandon et al Antimicrob. Agents Chemother. 54, 1111-6, (2010)

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Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. Xiaoping Xu et al Antimicrob. Agents Chemother. 54, 1152-9, (2010)

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Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Mirva Lehtopolku et al Antimicrob. Agents Chemother. 54, 1232-6, (2010)

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Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. Tsai-Ling Lauderdale et al Antimicrob. Agents Chemother. 54, 1338-42, (2010)

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Detection of KPC in Acinetobacter spp. in Puerto Rico. Iraida E Robledo et al Antimicrob. Agents Chemother. 54, 1354-7, (2010)

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In vitro pharmacodynamics of levofloxacin and other aerosolized antibiotics under multiple conditions relevant to chronic pulmonary infection in cystic fibrosis. Paula King et al Antimicrob. Agents Chemother. 54, 143-8, (2010)

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Fluoroquinolone resistance in Streptococcus dysgalactiae subsp. equisimilis and evidence for a shared global gene pool with Streptococcus pyogenes. M D Pinho et al Antimicrob. Agents Chemother. 54, 1769-77, (2010)

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Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. Emma Padilla et al Antimicrob. Agents Chemother. 54, 177-83, (2010)

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Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Matthew G Blango et al Antimicrob. Agents Chemother. 54, 1855-63, (2010)

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In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Brian J Morrow et al Antimicrob. Agents Chemother. 54, 1955-64, (2010)

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Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. Steven D Brown et al Antimicrob. Agents Chemother. 54, 2063-9, (2010)

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Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. Yu-Chi Lin et al Antimicrob. Agents Chemother. 54, 2078-84, (2010)

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Worldwide experience with the use of doripenem against extended-spectrum-beta-lactamase-producing and ciprofloxacin-resistant Enterobacteriaceae: analysis of six phase 3 clinical studies. Koné Kaniga et al Antimicrob. Agents Chemother. 54, 2119-24, (2010)

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In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 54, 2273-5, (2010)

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In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Pamela McGhee et al Antimicrob. Agents Chemother. 54, 230-8, (2010)

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Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. Renato Pires et al Antimicrob. Agents Chemother. 54, 2677-80, (2010)

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In vitro activities of DC-159a, a novel fluoroquinolone, against Mycobacterium species. Areeya Disratthakit et al Antimicrob. Agents Chemother. 54, 2684-6, (2010)

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Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. Moran G Goren et al Antimicrob. Agents Chemother. 54, 2687-91, (2010)

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In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 54, 2704-6, (2010)

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Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Michael R Jacobs et al Antimicrob. Agents Chemother. 54, 2716-9, (2010)

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Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). Emilio Pérez-Trallero et al Antimicrob. Agents Chemother. 54, 2953-9, (2010)

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Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. Azita Leavitt et al Antimicrob. Agents Chemother. 54, 3002-6, (2010)

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In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center. Michael J Zapor et al Antimicrob. Agents Chemother. 54, 3015-7, (2010)

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Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). Daryl J Hoban et al Antimicrob. Agents Chemother. 54, 3031-4, (2010)

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Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART). Stephen P Hawser et al Antimicrob. Agents Chemother. 54, 3043-6, (2010)

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Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. Il Kwon Bae et al Antimicrob. Agents Chemother. 54, 3068-9, (2010)

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In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Michael J Pucci et al Antimicrob. Agents Chemother. 54, 3478-80, (2010)

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Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. Linda K McDougal et al Antimicrob. Agents Chemother. 54, 3804-11, (2010)

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Bioavailability and efficacy of levofloxacin against Francisella tularensis in the common marmoset (Callithrix jacchus). Michelle Nelson et al Antimicrob. Agents Chemother. 54, 3922-6, (2010)

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Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. Michelle M Butler et al Antimicrob. Agents Chemother. 54, 3974-7, (2010)

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In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. Yun Cai et al Antimicrob. Agents Chemother. 54, 3998-9, (2010)

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Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 54, 4009-11, (2010)

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Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. Hidemasa Nakaminami et al Antimicrob. Agents Chemother. 54, 4107-11, (2010)

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Impact of recA on levofloxacin exposure-related resistance development. Renu Singh et al Antimicrob. Agents Chemother. 54, 4262-8, (2010)

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Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. Suzanne Bialek et al Antimicrob. Agents Chemother. 54, 4373-8, (2010)

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The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins. Hsun-Cheng Su et al Antimicrob. Agents Chemother. 54, 4626-35, (2010)

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Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. Alka Khanna et al Antimicrob. Agents Chemother. 54, 4789-93, (2010)

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Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS. Jun-Ren Sun et al Antimicrob. Agents Chemother. 54, 4934-8, (2010)

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In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. Paul G Higgins et al Antimicrob. Agents Chemother. 54, 5021-7, (2010)

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Effect of N-1/c-8 ring fusion and C-7 ring structure on fluoroquinolone lethality. Muhammad Malik et al Antimicrob. Agents Chemother. 54, 5214-21, (2010)

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In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. Manuela Donati et al Antimicrob. Agents Chemother. 54, 5379-80, (2010)

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Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Julien Brillault et al Antimicrob. Agents Chemother. 54, 543-5, (2010)

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In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. Catharine C Bulik et al Antimicrob. Agents Chemother. 54, 557-9, (2010)

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SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. María B Sánchez et al Antimicrob. Agents Chemother. 54, 580-1, (2010)

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Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. Songmee Bae et al Antimicrob. Agents Chemother. 54, 65-71, (2010)

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Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. Kim Credito et al Antimicrob. Agents Chemother. 54, 673-7, (2010)

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Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. Lucia Pallecchi et al Antimicrob. Agents Chemother. 54, 678-82, (2010)

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Transferable quinolone resistance in Vibrio cholerae. Hong Bin Kim et al Antimicrob. Agents Chemother. 54, 799-803, (2010)

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Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. Milagrosa Montes et al Antimicrob. Agents Chemother. 54, 93-7, (2010)

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Membrane transporters in drug development Giacomini, K.M., et al. Nat. Rev. Drug Discov. 9, 215-236, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). Ha Young Kim et al J. Med. Chem. 54, 3268-82, (2011)

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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity. Folkert Reck et al J. Med. Chem. 54, 7834-47, (2011)

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Design, synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl)fluoroquinolone derivatives. Yun Chai et al Bioorg. Med. Chem. Lett. 21, 3377-80, (2011)

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Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives. Yibin Zhang et al Bioorg. Med. Chem. Lett. 21, 928-31, (2011)

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Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents. Salah A Al-Trawneh et al Bioorg. Med. Chem. 19, 2541-8, (2011)

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Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-4-amino-4-methylpiperidin-1-yl) fluoroquinolone derivatives. Ju-Xian Wang et al Eur. J. Med. Chem. 46, 2421-6, (2011)

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Synthesis and in vitro antibacterial activity of a series of novel gatifloxacin derivatives. Yun Chai et al Eur. J. Med. Chem. 46, 4267-73, (2011)

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Synthesis of lipophilic dimeric C-7/C-7-linked ciprofloxacin and C-6/C-6-linked levofloxacin derivatives. Versatile in vitro biological evaluations of monomeric and dimeric fluoroquinolone derivatives as potential antitumor, antibacterial or antimycobacterial agents. Joëlle Azéma et al Eur. J. Med. Chem. 46, 6025-38, (2011)

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In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. A Briales et al Antimicrob. Agents Chemother. 55, 1266-9, (2011)

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Streptothricin derivatives from Streptomyces sp. I08A 1776. Maoluo Gan et al J. Nat. Prod. 74, 1142-7, (2011)

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Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii. Juan Liu et al J. Nat. Prod. 74, 1826-9, (2011)

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