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30432 Sigma

Dansylcadaverine

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Synonym: N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine

  • CAS Number 10121-91-2

  • Empirical Formula (Hill Notation) C17H25N3O2S

  • Molecular Weight 335.46

  •  Beilstein Registry Number 2951070

  •  EC Number 233-326-9

  •  MDL number MFCD00042704

  •  PubChem Substance ID 57648439

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Properties

Related Categories Alphabetical, Autophagy, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   MLEBFEHOJICQQS-UHFFFAOYSA-N
product line   BioReagent
assay   ≥99.0% (HPLC)
mp   137-140 °C
fluorescence   λex 335 nm; λem 518 nm in methanol
  λex 338 nm; λem 500 nm (Reaction product)
solubility   Do you have solubility information on this product that you would like to share?
suitability   suitable for fluorescence
storage temp.   −20°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

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Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes.

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Other Notes

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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