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31395 Sigma

Dextran sulfate sodium salt from Leuconostoc spp.

Mr ~500,000

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Properties

form   powder
mol wt   Mr ~500,000
composition   Sulfur Content, 16.0-19.0%
solubility   H2O: freely soluble50 mg/mL, clear
anion traces   chloride (Cl-): ≤100 mg/kg
cation traces   Ca: ≤200 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤1000 mg/kg
  Mg: ≤100 mg/kg
  Mn: ≤5 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Preparation Note

prepared from dextran with Mr ~500,000

Application

Dextran sulfate sodium salt from Leuconostoc sp. was used as a test compound for studying the heparin and dextran sulphate interaction with alkali ions. It has was used for releasing DNA from DNA-histone complexes.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength.The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
HH9290000
Protocols & Articles
Peer-Reviewed Papers
15

References

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