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31404 Sigma

Dextran sulfate sodium salt from Leuconostoc spp.

Mr 5,000

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Dextran Sulfates for General Research Applications, Dextrans
form   powder
mol wt   Mr 5,000
composition   Sulfur Content, 16.0-20.0%
loss   ≤10% loss on drying
solubility   H2O: soluble0.1 g/mL, clear, colorless to slightly yellow
  H2O: freely soluble50 mg/mL, clear

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Preparation Note

prepared from dextran with Mr ~5000

Application

Dextran sulfate sodium salt from Leuconostoc sp. is a polyanion used as a test reagent for testing its capability to rupture the extracellular enveloped virus (EEV) outer membrane. It has also been used for assessing the impact of TLR4 monoclonal antibody on the growth of dextran-sulfate-sodium-(DSS)-induced colitis.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
HH9290000
Protocols & Articles

Articles

Dextran and Related Polysaccharides

Historically, dextrans had been long recognized as contaminants in sugar processing and other food production. The formation of dextran in wine was shown by Pasteur to be due to the activity of micro...
Vicki Caligur
BioFiles 2008, 3.10, 17.
Keywords: Adhesion, Applications, Chromatography, Clinical, Cosmetics, Derivatizations, Diffusion, Filtration, Immobilization, Industries, Ion Exchange, Ligands, Microscopy, Molecular biology, Molecular biology techniques, Nuclear magnetic resonance spectroscopy, Nucleic acid hybridization, Pharmaceutical, Precipitation, Purification, Separation, Size-exclusion chromatography, Spectroscopy, Sulfations, Type

FITC-labelled polysaccharides

FITC-Dextran FITC-DEAE-dextran (FDD) FITC-carboxymethyl-dextran (FCM-Dextran) FITC-polysucrose (FITC-Ficoll®) FITC-DEAE-polysucrose FITC-CM-polysucrose (FITC-CM-Ficoll®) FITC-inulin Fluorescein hyalu...
Keywords: Absorption, Amidations, Bacterial conjugations, Cosmetics, Diabetes, Diagnostic, Esterifications, Filtration, Microscopy, Pharmaceutical, Separation, Size-exclusion chromatography, Solvents, Substitutions, Transfection

Peer-Reviewed Papers
15

References

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