EMAIL THIS PAGE TO A FRIEND
31995 Sigma

Barbital

BioXtra, ≥99.0% (T)

Synonym: 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 5,5-Diethylbarbituric acid, Barbitone, Veronal

  • CAS Number 57-44-3

  • Empirical Formula (Hill Notation) C8H12N2O3

  • Molecular Weight 184.19

  •  Beilstein Registry Number 163999

  •  EC Number 200-331-2

  •  MDL number MFCD00036212

  •  PubChem Substance ID 57648640

Purchase

Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Barbiturate Standards, Barbiturates,
InChI Key   FTOAOBMCPZCFFF-UHFFFAOYSA-N
product line   BioXtra
assay   ≥99.0% (T)
drug control   USDEA Schedule IV; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
ign. residue   ≤0.1% (as SO4)
loss   ≤0.5% loss on drying, 20 °C (HV)
mp   189-191 °C
solubility   alcohol: soluble 1 gm in 14 ml
  chloroform: soluble 1 gm in 75 ml
  diethyl ether: soluble 1 gm in 35 ml
  water: soluble 1 gm in 13 ml (boiling)
  water: soluble 1 gm in 130 ml
  acetone: soluble
  ethyl acetate: soluble
  nitrobenzene: soluble
  petroleum ether: soluble
  pyridine: soluble
anion traces   chloride (Cl-): ≤500 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Ca: ≤50 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤200 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Biochem/physiol Actions

Sedative/hypnotic

Barbital also referred to as 5,5-Diethylbarbituric acid, Barbitone or Veronal is a sedative/hypnotic (sleeping aid). It stimulates the development of tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN).

Other Notes

Sales restrictions may apply

Application

Barbital has been used as an assay buffer for determining the carbonic anhydrase activity. It has also been used for rocket immunoelectrophoresis.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CQ3500000
Protocols & Articles

Articles

HPLC Analysis of Barbiturates on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Ascentis® C18
Keywords: Anticonvulsants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical, Separation, Solvents

HPLC Analysis of Barbiturates on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Ascentis® C8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® C18, Unbuffered Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® C18, Unbuffered Mobile Phase
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® C8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® RP-AmideC16
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

UHPLC Analysis of Barbiturates on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Barbiturates on Titan™ C18
Keywords: Anti-depressants, Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?