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360376 Sigma

Capsaicin

natural

Synonym: 8-Methyl-N-vanillyl-trans-6-nonenamide

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Properties

Related Categories Alkaloid, Amides, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Building Blocks,
grade   natural
InChI Key   YKPUWZUDDOIDPM-SOFGYWHQSA-N
assay   63.7% (HPLC)
composition   capsaicin, 65%
  dihydrocapsaicin, 35%
mp   62-65 °C(lit.)
solubility   chloroform: soluble5%
Gene Information   human ... CYP1A2(1544), TRPV1(7442)
rat ... Trpv1(83810), Trpv4(66026)

Description

Packaging

1 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
RA8530000
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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