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36801 Sigma

7-(Diethylamino)coumarin-3-carboxylic acid N-succinimidyl ester

BioReagent, suitable for fluorescence, ≥96.0% (HPLC)

Synonym: N-Succinimidyl 7-(diethylamino)coumarin-3-carboxylate

  • CAS Number 139346-57-9

  • Empirical Formula (Hill Notation) C18H18N2O6

  • Molecular Weight 358.35

  •  Beilstein Registry Number 5359433

  •  MDL number MFCD00467585

  •  PubChem Substance ID 57649664

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Properties

Related Categories Biochemicals and Reagents, Detection, Dialkylcarbocyanine and Styryl probes, Fluorescent Indicators and Probes, Fluorescent Labels,
InChI Key   NUNPVRICKDZFLK-UHFFFAOYSA-N
product line   BioReagent
assay   ≥96.0% (HPLC)
solubility   DMF: soluble
  DMSO: soluble
  acetonitrile: soluble
fluorescence   λex 445 nm; λem 482 nm in 0.1 M phosphate pH 7.0
suitability   corresponds for coupling to amines
  suitable for fluorescence
storage temp.   −20°C

Description

Other Notes

Labeling of amino acids prior to resolution by capillary zone electrophoresis

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

7-(Diethylamino)coumarin-3-carboxylic acid N-succinimidyl ester is used as a reagent to conjugate 7-(diethylamino)coumarin-3-carboxylic acid (7-DCCA) to other molecules such as amino acids via amide chemistry. 7-DCCA is used to label amino acids prior to resolution by capillary zone electrophoresis. 7-DCCA is used as a reference in screening of nerve agent degradation products by MALDI-TOFMS.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

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Labeling peptides with fluorescent dyes or other labels provides powerful tools for the investigation of biological relevant interactions like receptor-ligand-binding,1-3 protein structures,4-6 and e...
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Keywords: Alzheimer Disease, Biochemistry, Electrophoresis, Enzyme activity, Immobilization, Ligands, Methods, Microscopy, Peptide synthesis, Separation, Solid phase peptide synthesis, Solvents, Spectroscopy, Tools

Sensor Dyes

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Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

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