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42364 Sigma

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate

BioReagent, suitable for fluorescence, ≥98.0% (TLC)

Synonym: DiI

  • CAS Number 41085-99-8

  • Empirical Formula (Hill Notation) C59H97ClN2O4

  • Molecular Weight 933.87

  •  Beilstein Registry Number 8251870

  •  MDL number MFCD00142354

  •  PubChem Substance ID 57650110

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Detection, Dialkylcarbocyanine and Styryl probes, Fluorescent Indicators and Probes,
InChI Key   JVXZRNYCRFIEGV-UHFFFAOYSA-M
product line   BioReagent
assay   ≥98.0% (TLC)
mp   68 °C (dec.)(lit.)
solubility   DMF: soluble
  DMSO: soluble
  methanol: soluble
fluorescence   λex 550 nm; λem 567 nm in phosphate buffer/SDS pH 7.0
suitability   suitable for fluorescence

Description

Biochem/physiol Actions

Lipophilic carbocyanine dye used primarily for optical recordings of membrane voltage and for studies of membrane fluidity. Retrograde stain for neurons; provides intense, long-lasting staining of live neurons in vivo and in vitro.

Other Notes

Lipophilic fluorescent probe for studying membranes

Application

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate is used for the following applications:
• Preparation of Dil solution
• fluorescent membrane dye
• Di-I Staining

General description

DiI is a Dye Aye, a chemical with CAS number 41085-99-8. It is a fluorescent lipophilic cationic indocarbocyanine dye, which is usually made as a perchlorate salt. Mostly used for scientific staining purposes, such as single molecule imaging, fate mapping and neuronal tracing (as DiI is retained in the lipid bilayers).

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

References

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