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43420 Sigma

β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

≥97.0% (HPLC)

Synonym: β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH

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Properties

Related Categories Biochemicals and Reagents, Bulk vials, NAD(P)(H) and Analogs, NADH, Nucleosides, Nucleotides, Oligonucleotides More...
InChI Key   FWBNCIFELNNJCX-UHOVGGJYSA-L
assay   ≥97.0% (HPLC)
cation traces   Ca: ≤200 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤20 mg/kg
  Fe: ≤5 mg/kg
  K: ≤200 mg/kg
  Mg: ≤200 mg/kg
  Mn: ≤5 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg
absorbance ratio   A260/340 nm ≤2.40
storage temp.   2-8°C

Description

Packaging

Packaged by solid weight.

Application

As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Nicotinamide adenine dinucleotide (NAD) and NADH form a redox pair. NAD/NADH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications. NAD is also involved in post-translational (Poly(ADP-ribose) polymerization) modifications of proteins.

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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