Doxorubicin hydrochloride

Papers

1. Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momparler RL, Karon M, et al. Cancer Res. 36, 2891-2895, (1976)

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2. Protective role of Nd1 in doxorubicin-induced cardiotoxicity. Lisa Fujimura, Yuji Matsudo, et al. Cardiovasc. Res. 64, 315-321, (2004)

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3. RET Activation Inhibits Doxorubicin-induced Apoptosis in SK-N-MC Cells. MICHAEL A. SKINNER, et al. Anticancer Res. 28, 2019-2025, (2008)

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4. Effect of adriamycin on heart mitochondrial DNA. C.N. Ellis et al. Biochem. J. 245, 309, (1987)

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5. R.J. White et al. Drugs Pharm. Sci. 22, 569, (1984)

6. A. Vigevani, M.J. Williamson Anal. Profiles Drug Subst. 9, 245, (1980)

A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide. Jin Kyu Kim et al Bioorg. Med. Chem. Lett. 15, 3576-9, (2005)

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Bioactive guaianolides from siyekucai (Ixeris chinensis). Shujun Zhang et al J. Nat. Prod. 69, 1425-8, (2006)

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Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum. Mira M Konopleva et al J. Nat. Prod. 69, 394-6, (2006)

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Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Anne Zuse et al J. Med. Chem. 50, 6059-66, (2007)

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Anti-tumor 12-deoxyphorbol esters from Euphorbia cornigera. Imam Bakhsh Baloch et al Eur. J. Med. Chem. 43, 274-81, (2008)

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Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. Hee-Ju Cho et al Bioorg. Med. Chem. Lett. 19, 6766-9, (2009)

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Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. Hee-Kyung Rhee et al Bioorg. Med. Chem. 17, 7537-41, (2009)

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Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity. Le Thi Kim Van et al J. Nat. Prod. 72, 1419-23, (2009)

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Bioactive alkaloids from endophytic Aspergillus fumigatus. Hui Ming Ge et al J. Nat. Prod. 72, 753-5, (2009)

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A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. He Huang et al J. Med. Chem. 53, 3048-64, (2010)

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Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. Ji-Hye Kang et al Bioorg. Med. Chem. Lett. 20, 1008-12, (2010)

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Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. Sham M Sondhi et al Bioorg. Med. Chem. Lett. 20, 2306-10, (2010)

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Two novel neo-clerodane diterpenoids from Scutellaria barbata. Hanna Lee et al Bioorg. Med. Chem. Lett. 20, 288-90, (2010)

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Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 20, 3310-3, (2010)

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Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Zhiyong Chen et al Bioorg. Med. Chem. Lett. 20, 3876-9, (2010)

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2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Arjun Basnet et al Bioorg. Med. Chem. Lett. 20, 42-7, (2010)

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New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. Hee-Ju Cho et al Bioorg. Med. Chem. 18, 1010-7, (2010)

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Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Pritam Thapa et al Bioorg. Med. Chem. 18, 2245-54, (2010)

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Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. Radha Karki et al Bioorg. Med. Chem. 18, 3066-77, (2010)

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2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Pritam Thapa et al Bioorg. Med. Chem. 18, 377-86, (2010)

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Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. Guang-min Xi et al Bioorg. Med. Chem. 18, 6725-33, (2010)

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Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2. Karen A Nolan et al Bioorg. Med. Chem. 18, 696-706, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones. K Effenberger et al Eur. J. Med. Chem. 45, 1947-54, (2010)

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Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity. Hideaki Yamaguchi et al Eur. J. Med. Chem. 45, 2943-8, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Georg Surkau et al Eur. J. Med. Chem. 45, 3354-64, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Holger C Nickel et al Eur. J. Med. Chem. 45, 3420-38, (2010)

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Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. Ahmed Kamal et al Eur. J. Med. Chem. 45, 3870-84, (2010)

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Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. Ahmed Kamal et al Eur. J. Med. Chem. 45, 3924-37, (2010)

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Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. Sangwook Woo et al Eur. J. Med. Chem. 45, 4221-8, (2010)

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Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. Luke D Jasenosky et al Antimicrob. Agents Chemother. 54, 3007-10, (2010)

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Cytotoxic triterpenoids from Maytenus retusa. Sandra M Oramas-Royo et al J. Nat. Prod. 73, 2029-34, (2010)

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Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. Masahiko Isaka et al J. Nat. Prod. 73, 688-92, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents. Jing Li et al Bioorg. Med. Chem. Lett. 21, 130-2, (2011)

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Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives. Feng Shi et al Bioorg. Med. Chem. Lett. 21, 1554-8, (2011)

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Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Pu Zhang et al Bioorg. Med. Chem. Lett. 21, 338-41, (2011)

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An efficient one-pot synthesis of benzothiazolo-4?-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 21, 350-3, (2011)

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Constructing transferrin receptor targeted drug delivery system by using doxorubicin hydrochloride and vanadocene dichloride. Yanxia Zhang et al Bioorg. Med. Chem. Lett. 21, 5982-6, (2011)

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Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents Kamal, A.; et al. Bioorg. Med. Chem. 19, 2349, (2011)

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Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. Ahmed Kamal et al Bioorg. Med. Chem. 19, 2565-81, (2011)

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Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase II? catalytic inhibitor. Kyu-Yeon Jun et al Eur. J. Med. Chem. 46, 1964-71, (2011)

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Synthesis of 4?-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. Hong Chen et al Eur. J. Med. Chem. 46, 4709-14, (2011)

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Synthesis and biological evaluation of 1,9-disubstituted ?-carbolines as potent DNA intercalating and cytotoxic agents. Zhiyong Chen et al Eur. J. Med. Chem. 46, 5127-37, (2011)

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Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. Ahmed Kamal et al Eur. J. Med. Chem. 46, 691-703, (2011)

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Efficient microwave-assisted synthesis of novel 3-aminohexahydrocoumarin derivatives and evaluation on their cytotoxicity. Feng Shi et al Eur. J. Med. Chem. 46, 953-60, (2011)

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Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment. Carmen Schleissner et al J. Nat. Prod. 74, 1590-6, (2011)

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Lanostane and hopane triterpenes from the entomopathogenic fungus Hypocrella sp. BCC 14524. Masahiko Isaka et al J. Nat. Prod. 74, 2143-50, (2011)

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Trigonosins A-F, daphnane diterpenoids from Trigonostemon thyrsoideum. Shi-Fei Li et al J. Nat. Prod. 74, 464-9, (2011)

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Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. Masahiko Isaka et al J. Nat. Prod. 74, 782-9, (2011)

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Synthesis and evaluation of cytotoxic effects of novel ?-methylenelactone tetracyclic diterpenoids. Yao-Fu Zeng et al Bioorg. Med. Chem. Lett. 22, 1922-5, (2012)

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Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. I Kraicheva et al Bioorg. Med. Chem. 20, 117-24, (2012)

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Cytotoxic drugs and the CD95 pathway. Friesen, C., et al. Leukemia 13, 1854, (1999)

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Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin. Kraus-Berthier, L, et al. Cancer Res. 6, 297-304, (2000)

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Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Sparano, J.A. Semin. Oncol. 26, 14-19, (1999)

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Merck 14,3439

Aldrich MSDS 1, 849:A / Corp MSDS 1 (1), 1499:A / RegBook 1 (2), 1691:D / Sax 6, 144 / Structure Index 1, 268:B:6