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44583 Sigma

Doxorubicin hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

Synonym: DOX, Hydroxydaunorubicin hydrochloride

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
biological source   from synthetic
material   orange to dark red
InChI Key   MWWSFMDVAYGXBV-RUELKSSGSA-N
assay   98.0-102.0% (HPLC)
form   solid
mp   216 °C (dec.)(lit.)
solubility   H2O: soluble50 mg/mL, clear, orange to red
  DMSO: soluble
  THF: soluble
  ethanol: soluble
  methanol: soluble
fluorescence   λex 470 nm; λem 585 nm in ethanol
suitability   suitable for fluorescence
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   neoplastics
storage temp.   2-8°C

Description

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Application

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Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Packaging

1, 10, 50 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

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Flow Cytometry Instruments
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QI9295900

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Applications of Graphene Oxide and Reduced Graphene Oxide

Graphene oxide (GO, Aldrich product numbers 763705 and 777676) is a unique material that can be viewed as a single monomolecular layer of graphite with various oxygen containing functionalities such ...
Avery Luedtke, Ph.D.
Aldrich Materials Science, Sigma-Aldrich Co. LLC
Keywords: Cancer, Catalysis, Materials Science, Nanomaterials, Reductions, Semiconductor, Solar cells

Inhibition of Nucleic Acid Synthesis by Antibiotics

Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication. DNA gyra...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antitumor agents, Cancer, DNA replication

Peer-Reviewed Papers
15

References

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