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46121 Sigma

Resorufin ethyl ether

suitable for fluorescence, ≥95% (UV)

Synonym: 7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin

  • CAS Number 5725-91-7

  • Empirical Formula (Hill Notation) C14H11NO3

  • Molecular Weight 241.24

  •  Beilstein Registry Number 225973

  •  MDL number MFCD00037661

  •  PubChem Substance ID 329757074

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Flow Cytometry,
InChI Key   ZOSYTBPPLWBBKM-UHFFFAOYSA-N
assay   ≥95% (UV)
mp   223-225 °C(lit.)
solubility   DMF: soluble
  DMSO: soluble
  alcohols: soluble
fluorescence   λex 464 nm; λem 540 nm in methanol(lit.)
  λex 571 nm; λem 585 nm in dealkylase(lit.)
suitability   suitable for fluorescence
storage temp.   2-8°C

Description

Other Notes

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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