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46944 Sigma

Fluorescein isothiocyanate–dextran

average mol wt 4,000, (FITC:Glucose = 1:250)

Synonym: FITC–Dextran, FITC-Dextran 4

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Fluorescent Conjugates, Fluorescent Conjugates for Flow Cytometry, Fluorescent Indicators and Probes,
assay   (FITC:Glucose = 1:250)
mol wt   average mol wt 4,000
extent of labeling   ~0.004 mol/mol FITC glucose
solubility   H2O: 50 mg/mL, slightly hazy, orange
storage temp.   2-8°C

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. FITC-dextran has been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran.
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination
Fluorescein isothiocyanate–dextran (FITC-Dextran 4) is use as a fluorescent probe to study cell permeability. FITC-Dextran 4 is used with to study permeability of epithelial cell such as intestinal and renal cells in vivo.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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