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46945 Sigma

Fluorescein isothiocyanate–dextran

average mol wt 70,000, (FITC:Glucose = 1:250)

Synonym: FITC–Dextran, FITC-Dextran 70

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Carbohydrates, Core Bioreagents, Detection,
assay   (FITC:Glucose = 1:250)
mol wt   average mol wt 70,000
extent of labeling   ~0.004 mol/mol FITC glucose
solubility   H2O: 50 mg/mL hazy, orange to very deep orange
fluorescence   λex 492 nm; λem 518 nm in ethanol
storage temp.   2-8°C

Description

Other Notes

Internalisation of FITC and FITC-dextran by suspension cultured plant cells; In the study of fluid pinocytosis in leukocytes

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

Fluorescein isothiocyanate–dextran (FITC-Dextran 70) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-Dextran 70 may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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