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47568 Sigma

5-Fluoro-L-tryptophan

≥98.0% (HPLC)

  • CAS Number 16626-02-1

  • Empirical Formula (Hill Notation) C11H11FN2O2

  • Molecular Weight 222.22

  •  Beilstein Registry Number 5052680

  •  MDL number MFCD00066470

  •  PubChem Substance ID 57651014

  •  eCl@ss 32160406

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Properties

Related Categories Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Type,
InChI Key   INPQIVHQSQUEAJ-VIFPVBQESA-N
assay   ≥98.0% (HPLC)
optical purity   enantiomeric ratio: ≥99.5:0.5 (HPLC)
storage temp.   2-8°C

Description

Application

Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.

Packaging

25 mg in poly bottle

Biochem/physiol Actions

5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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