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47612 Sigma

Folinic acid calcium salt hydrate

BioXtra, ≥99.0% (HPLC)

Synonym: 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

  • CAS Number 1492-18-8 (anhydrous)

  • Empirical Formula (Hill Notation) C20H21CaN7O7 · xH2O

  • Molecular Weight 511.50 (anhydrous basis)

  •  Beilstein Registry Number 5723924

  •  PubChem Substance ID 24871209

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Coenzymes and Cofactors, Folic Acid, Folic Acid Metabolism,
product line   BioXtra
assay   ≥99.0% (HPLC)

Description

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

General description

Calcium salt of the (6R,S)-mixture of diastereomers of 5-formyl-5,6,7,8-tetrahydrofolate.

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Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

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