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47989 Sigma

Fura 2-AM

BioReagent, suitable for fluorescence, ≥95.0% (HPLC)

Synonym: Fura-2 pentakis(acetoxymethyl) ester

  • CAS Number 108964-32-5

  • Empirical Formula (Hill Notation) C44H47N3O24

  • Molecular Weight 1001.85

  •  Beilstein Registry Number 8183748

  •  MDL number MFCD00036976

  •  PubChem Substance ID 57651141

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Properties

Related Categories Biochemicals and Reagents, Calcium Indicators, Chelators and Ion Probes, Chelators and Ion Probes for Flow Cytometry, Chelators and Ion Probes for Microscopy,
InChI Key   VPSRLGDRGCKUTK-UHFFFAOYSA-N
product line   BioReagent
assay   ≥95.0% (HPLC)
solubility   DMSO: soluble
fluorescence   λex 355 nm; λem 495 nm in 0.1 M Tris pH 8.0, esterase; 10 mM Ca2+
suitability   suitable for fluorescence
storage temp.   −20°C

Description

Other Notes

Membrane-permeable derivative of Fura-2. Used to load the chelator into cells. Hydrolysed enzymatically in the cell to yield Fura-2 which remains within the cell

Application

Fura-2 pentakis(acetoxymethyl) ester (Fura 2/AM), a fluorescence probe, is a membrane-permeable derivative of the calcium chelator Fura-2. Fura 2/AM is used to monitor intracellular levels of calcium under various physiological conditions.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

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