|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,|
|impurities||≤5% gramicidin C|
Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes.
Gramicidin A increases the permeability of bacterial cell membranes which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment 4.
Gramicidin A is a linear pentadecapeptide antibiotic which is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model 1,2,3.
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Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.
2. Gramicidin S: A Potent Inhibitor of Membrane-bound Epidennal Adenosine Triphosphatase from Nicotiana tabacum L. Leaves. Kunihiro Kasamo Plant Cell Physiol. 23, 195-204, (1982)
3. Gramicidin as a potential immunosuppressant for organ transplantation: suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat. T Hirano, K Oka, and T Tamaki J. Pharmacol. Exp. Ther. 273, 223, (1995)
4. Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases. Francisco J. Alvarez-Leefmans; Eric Delpire, et.al Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases, (2009), 142
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