|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,|
|impurities||≤5% gramicidin C|
Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes.
Gramicidin A increases the permeability of bacterial cell membranes which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment 4.
Gramicidin A is a linear pentadecapeptide antibiotic which is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model 1,2,3.
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Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.
2. Gramicidin S: A Potent Inhibitor of Membrane-bound Epidennal Adenosine Triphosphatase from Nicotiana tabacum L. Leaves. Kunihiro Kasamo Plant Cell Physiol. 23, 195-204, (1982)
3. Gramicidin as a potential immunosuppressant for organ transplantation: suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat. T Hirano, K Oka, and T Tamaki J. Pharmacol. Exp. Ther. 273, 223, (1995)
Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Bruno MJ, Rusinova R, Gleason NJ, et al. Faraday Discuss. 161, 461-80; discussion 563-89, (2013)
Selective and ATP-driven transport of ions across supported membranes into nanoporous carriers using gramicidin A and ATP synthase. Oliynyk V, Mille C, Ng JB, et al. Phys. Chem. Chem. Phys. 15(8), 2733-40, (2013)
Direct surfactin-gramicidin S antagonism supports detoxification in mixed producer cultures of Bacillus subtilis and Aneurinibacillus migulanus. Rautenbach M, Eyéghé-Bickong HA, Vlok NM, et al. Microbiology 158(Pt 12), 3072-82, (2012)
Effect of the addition of alkanols of different topology to dipalmitoyl-phosphatidylcholine vesicles in the presence of gramicidin. Soto-Arriaza MA, Olivares-Ortega C, and Lissi EA J. Colloid. Interface Sci. 385(1), 48-57, (2012)
Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes. Kozuch J, Steinem C, Hildebrandt P, et al. Angew. Chem. Int. Ed. Engl. 51(32), 8114-7, (2012)
4. Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases. Francisco J. Alvarez-Leefmans; Eric Delpire, et.al Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases, (2009), 142
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