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50845 Sigma

Gramicidin A from Bacillus brevis

≥90% (HPLC)

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
biological source   from Bacillus brevis
material   colorless or white
InChI Key   ZWCXYZRRTRDGQE-LUPIJMBPSA-N
assay   ≥90% (HPLC)
form   powder
impurities   ≤5% gramicidin C
  ≤5% water
solubility   ethanol: soluble
Mode of action   cell membrane | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Amino Acid Sequence

HCO-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH

Biochem/physiol Actions

Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes.

Gramicidin A increases the permeability of bacterial cell membranes which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment .

Application

Gramicidin A is a linear pentadecapeptide antibiotic which is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model .

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MD8230000
Protocols & Articles
Peer-Reviewed Papers
15

References

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