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50847 Sigma

Gramicidin C from Bacillus brevis

~90% (HPLC)

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
assay   ~90% (HPLC)
impurities   ≤5% water
Mode of action   cell membrane | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.

Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment .

Application

Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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