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50940 Sigma

Guanidine hydrochloride

≥99.0% (AT)

Synonym: Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

  • CAS Number 50-01-1

  • Linear Formula NH2C(=NH)NH2 · HCl

  • Molecular Weight 95.53

  •  Beilstein Registry Number 3591990

  •  EC Number 200-002-3

  •  MDL number MFCD00013026

  •  PubChem Substance ID 329757653

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Properties

InChI Key   PJJJBBJSCAKJQF-UHFFFAOYSA-N
assay   ≥99.0% (AT)
ign. residue   ≤0.1% (as SO4)
pH   (25 °C, 4.6 - 6/573 g/L)
mp   180-185 °C(lit.)
solubility   H2O: soluble6 M at 20 °C, clear, colorless
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Ca: ≤20 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Packaging

1 kg in poly bottle

10 g in poly bottle

100 g in glass bottle

5 kg in poly drum

500 g in poly bottle

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
MF4300000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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