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51280 Sigma

Hemin

BioXtra, from Porcine, ≥97.0% (HPLC)

Synonym: Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)

  • CAS Number 16009-13-5

  • Empirical Formula (Hill Notation) C34H32ClFeN4O4

  • Molecular Weight 651.94

  •  Beilstein Registry Number 5229914

  •  EC Number 240-140-1

  •  MDL number MFCD00010726

  •  PubChem Substance ID 24873656

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Hemin is used for the following applications:
• To study bacterial strains and growth conditions
• Used in short-term colony assays (the culture medium consists of hemin along with other components)
• Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Biochem/physiol Actions

Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.

Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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