|Related Categories||Application Index, Biochemicals and Reagents, Cell Biology, Enzymes, Inhibitors, and Substrates, Hemin,|
|biological source||from Porcine|
Live Chat and Frequently Asked Questions are available for this Product.
Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.
Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
Molecular cloning and expression of a cucumber (Cucumis sativus L.) heme oxygenase-1 gene, CsHO1, which is involved in adventitious root formation. Li MY, Cao ZY, Shen WB, Cui J. Gene 486, 47-55, (2011)
The hemophore HasA from Yersinia pestis (HasAyp) coordinates hemin with a single residue, Tyr75, and with minimal conformational change. Kumar R, Lovell S, Matsumura H, et al. Biochemistry 52(16), 2705-7, (2013)
The Bartonella quintana extracytoplasmic function sigma factor RpoE has a role in bacterial adaptation to the arthropod vector environment. Abromaitis S and Koehler JE J. Bacteriol. 195(11), 2662-74, (2013)
Oxidative stress is related to the deleterious effects of heme oxygenase-1 in an in vivo neuroinflammatory rat model. Tronel C, Rochefort GY, Arlicot N, et al. Oxid. Med. Cell. Longev. 2013, 264935, (2013)
Colorimetric assay for T4 polynucleotide kinase activity based on the horseradish peroxidase-mimicking DNAzyme combined with λ exonuclease cleavage. Jiang C, Yan C, Jiang J, et al. Anal. Chim. Acta 766, 88-93, (2013)
Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain. Santos RM, Rodrigues MS, Laranjinha J, et al. Biosens. Bioelectron. 44, 152-9, (2013)
[Effect of stress actions on some hematologic and biochemical parameters of rat blood and on energetic intermolecular interactions in lipid extract under effect of light radiation]. Zabelinskiĭ SA, Chebotareva MA, Tavrovskaia TV, et al. Zh. Evol. Biokhim. Fiziol. 48(6), 548-56, (2012)
Efficient quenching of electrochemiluminescence from K-doped graphene-CdS:Eu NCs by G-quadruplex-hemin and target recycling-assisted amplification for ultrasensitive DNA biosensing. Zhou H, Zhang YY, Liu J, et al. Chem. Commun. 49(22), 2246-8, (2013)
Photoinduced electron transfer of DNA/Ag nanoclusters modulated by G-quadruplex/hemin complex for the construction of versatile biosensors. Zhang L, Zhu J, Guo S, et al. J. Am. Chem. Soc. 135(7), 2403-6, (2013)
Multilayer hemin/G-quadruplex wrapped gold nanoparticles as tag for ultrasensitive multiplex immunoassay by chemiluminescence imaging. Zong C, Wu J, Xu J, et al. Biosens. Bioelectron. 43, 372-8, (2013)
Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. Thomas CP, Boeglin WE, Garcia-Diaz Y, et al. Chem. Phys. Lipids 167-168, 21-32, (2013)
Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms. Salas PF, Herrmann C, Cawthray JF, et al. J. Med. Chem. 56(4), 1596-613, (2013)
The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats. Jadhav A, Tiwari S, Lee P, et al. J. Pharmacol. Exp. Ther. 345(2), 239-49, (2013)
Dual functions of the C5a receptor as a connector for the K562 erythroblast-like cell-THP-1 macrophage-like cell island and as a sensor for the differentiation of the K562 erythroblast-like cell during haemin-induced erythropoiesis. Nishiura H, Zhao R, and Yamamoto T Clin. Dev. Immunol. 2012, 187080, (2012)
How close are we to developing enteric-protective drugs against non-steroidal anti-inflammatory drug-induced small intestinal injury? New mechanistic insight from preclinical models. Boelsterli UA J. Gastroenterol. Hepatol. 28(4), 589-90, (2013)
Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. María P. Sánchez-Cañete et al Antimicrob. Agents Chemother. 53, 1305-13, (2009)
Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. Sakai E, Shimada-Sugawara M, et al. J. Cell. Biochem. 113(2), 486-498, (2011)
Hemin/G-quadruplexes as DNAzymes for the fluorescent detection of DNA, aptamer-thrombin complexes, and probing the activity of glucose oxidase. Golub E, Freeman R, Niazov A, Willner I. Analyst 136(21), 4397-401, (2011)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?