|Related Categories||Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Hemin, Metabolic Pathways,|
|biological source||from Porcine|
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Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.
Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
Molecular cloning and expression of a cucumber (Cucumis sativus L.) heme oxygenase-1 gene, CsHO1, which is involved in adventitious root formation. Li MY, Cao ZY, Shen WB, Cui J. Gene 486, 47-55, (2011)
Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. María P. Sánchez-Cañete et al Antimicrob. Agents Chemother. 53, 1305-13, (2009)
Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. Sakai E, Shimada-Sugawara M, et al. J. Cell. Biochem. 113(2), 486-498, (2011)
Hemin/G-quadruplexes as DNAzymes for the fluorescent detection of DNA, aptamer-thrombin complexes, and probing the activity of glucose oxidase. Golub E, Freeman R, Niazov A, Willner I. Analyst 136(21), 4397-401, (2011)
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