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53300 Sigma

Histamine dihydrochloride

≥99.0% (AT)

Synonym: 2-(4-Imidazolyl)ethylamine dihydrochloride

  • CAS Number 56-92-8

  • Empirical Formula (Hill Notation) C5H9N3 · 2HCl

  • Molecular Weight 184.07

  •  Beilstein Registry Number 3624116

  •  EC Number 200-298-4

  •  MDL number MFCD00012703

  •  eCl@ss 32160406

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Substrates,
InChI Key   PPZMYIBUHIPZOS-UHFFFAOYSA-N
assay   ≥99.0% (AT)
ign. residue   ≤0.2%
loss   ≤0.2% loss on drying, 20 °C (HV)
mp   244-247 °C
  249-252 °C(lit.)
solubility   H2O: soluble0.1 g/mL, clear, colorless
anion traces   sulfate (SO42-): ≤200 ppm
cation traces   Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Other Notes

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection

Packaging

1, 5, 25 g in glass bottle

Biochem/physiol Actions

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.

General description

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

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Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MS1575000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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