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MilliporeSigma

53319

L-Histidine

≥99.5% (NT), BioUltra

Synonym(s):

(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

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25 G

$79.20

100 G

$265.00

$79.20

Estimated to ship onDecember 01, 2025Details

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About This Item

Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
71-00-1
Molecular Weight:
155.15
Beilstein/REAXYS Number:
84088
EC Number:
200-745-3
MDL number:
MFCD00064315
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57651378
NACRES:
NA.26

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Product Name

L-Histidine, BioUltra, ≥99.5% (NT)

product line

BioUltra

assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D −39±1°, c = 2% in H2O

impurities

insoluble matter, passes filter test
≤0.5% foreign amino acids

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 110 °C

color

white

pH

7.0-8.0 (25 °C, 0.1 M in H2O)

mp

282 °C (dec.) (lit.)
~285 °C (dec.)

solubility

H2O: 0.1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤500 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.1 M in H2O

UV absorption

λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

application(s)

detection

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759), CA2(760)

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1 of 4

This Item
H8000H6034H3911
L-Histidine BioUltra, ≥99.5% (NT)

Sigma-Aldrich

53319

L-Histidine

L-Histidine ReagentPlus®, ≥99% (TLC)

Sigma-Aldrich

H8000

L-Histidine

L-Histidine suitable for cell culture, meets EP, USP testing specifications, from non-animal source

Sigma-Aldrich

H6034

L-Histidine

L-Histidine

SAFC

H3911

L-Histidine

form

powder or crystals

form

powder

form

powder

form

crystalline powder

assay

≥99.5% (NT)

assay

≥99% (TLC)

assay

98.5-101.0%

assay

≥98.5%

product line

BioUltra

product line

ReagentPlus®

product line

-

product line

-

mp

282 °C (dec.) (lit.), ~285 °C (dec.)

mp

282 °C (dec.) (lit.)

mp

282 °C (dec.) (lit.)

mp

282 °C (dec.) (lit.)

color

white

color

white to off-white

color

white to off-white

color

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

400

Application

L-Histidine has been used for characterization of ZnO nanorod in an attempt to develop a technique for the ultra-low level detection of l-histidine.[1]

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.[2]
Precursor of histamine by action of histidine decarboxylase.

Other Notes

Amino acid spacing in isotachophoresis on polyacrylamide gels - a critical evaluation[3]; Prevents circular DNA strand cleavage in a xanthine-xanthine oxidase system[4]; Growth requirement of various microorganisms[5].

used together

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3872
BCCH8618
BCCF3353
BCCF0386
BCCB3337

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Ultra-Low Level Detection of L-Histidine Using Solution-Processed ZnO Nanorod on Flexible Substrate.
Sasmal M
IEEE Transactions on Nanobioscience, 14(6), 634-640 (2015)
K Brawn et al.
Acta physiologica Scandinavica. Supplementum, 492, 9-18 (1980-01-01)
An enzymic flux of O2- and H2O2 caused strand breaks in the supercoiled covalently closed circular Col El plasmid. Subnanomolar levels of superoxide levels of superoxide dismutase or of catalase prevented this attack on DNA, signifying that both O2- and
CRC Handbook of Microbiology, 4, 1-1 (1974)
Amino acid spacing in isotachophoresi; on polyacrylamide gel: a critical evaluation.
N Y Nguyen et al.
Analytical biochemistry, 94(1), 202-210 (1979-04-01)
Camilla Hofström et al.
Journal of medicinal chemistry, 56(12), 4966-4974 (2013-05-23)
Engineered affibody molecules can be used for high contrast in vivo molecular imaging. Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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