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53370 Sigma

L-Histidine monohydrochloride monohydrate

≥99.0% (AT)

Synonym: L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride

  • CAS Number 5934-29-2

  • Empirical Formula (Hill Notation) C6H9N3O2 · HCl · H2O

  • Molecular Weight 209.63

  •  Beilstein Registry Number 4168261

  •  MDL number MFCD00151027

  •  PubChem Substance ID 329757872

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Properties

Related Categories Amino Acids, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   CMXXUDSWGMGYLZ-XRIGFGBMSA-N
assay   ≥99.0% (AT)
optical activity   [α]20/D +9.5±0.5°, c = 5% in 5 M HCl
impurities   ≤0.3% foreign amino acids
mp   254 °C (dec.)(lit.)
solubility   H2O: soluble1 g/10 mL, clear, colorless (hot)
anion traces   sulfate (SO42-): ≤100 mg/kg
cation traces   Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  NH4+: ≤500 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

General description

L-Histidine is a hydrophilic essential amino acid that has a basic sidechain containing an imidazole group.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MS3119000

Documents

Certificate of Analysis

Protocols & Articles

Related Content

Amino Acids Reference Chart

The hydrophobicity index is a measure of the relative hydrophobicity, or how soluble an amino acid is in water. In a protein, hydrophobic amino acids are likely to be found in the interior, whereas h...

Peer-Reviewed Papers
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