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55155 Sigma

7-Hydroxycoumarin-3-carboxylic acid

suitable for fluorescence, ≥98.0% (TLC)

Synonym: Umbelliferone-3-carboxylic acid

  • CAS Number 779-27-1

  • Empirical Formula (Hill Notation) C10H6O5

  • Molecular Weight 206.15

  •  Beilstein Registry Number 384141

  •  MDL number MFCD00017491

  •  PubChem Substance ID 57651515

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Properties

Related Categories Alphabetical, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Detection,
InChI Key   LKLWLDOUZJEHDY-UHFFFAOYSA-N
assay   ≥98.0% (TLC)
pKa    7.04
mp   261 °C(lit.)
solubility   DMF: soluble
  DMSO: soluble
  alcohols: soluble
fluorescence   λex 342 nm; λem 447 nm (pH 4.0)
  λex 386 nm; λem 448 nm in 0.1 M Tris pH 9.0
suitability   suitable for fluorescence

Description

Other Notes

Immobilized on a support to give a pH sensor

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

7-Hydroxycoumarin-3-carboxylic acid (7-OHCCA) is used as a fluorogenic substrate for glycosyltransferase assays. 7-OHCCA may be used as a non-cinnamate-class substrate analog to study 4-hydroxycinnamate decarboxylase (4-HCD)-inducing activity in Klebsiella oxytoca cells.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

References

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