Synonym: 4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone, Cyclo werrol, Hypericum red
|Related Categories||Bioactive Small Molecules, Cell Biology, Glycosides, Including Glucosinolates, H, Hypericum perforatum (St John′s wort),|
Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria.
Bottomless glass bottle. Contents are inside inserted fused cone.
Bcl-2 proapoptotic proteins distribution in U-87 MG glioma cells before and after hypericin photodynamic action. Balogová L, Maslaňáková M, Dzurová L, et al. Gen. Physiol. Biophys. 32(2), 179-87, (2013)
Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. Li J, Cona MM, Chen F, et al. Theranostics 3(2), 127-37, (2013)
Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. Penjweini R, Loew HG, Eisenbauer M, et al. J. Photochem. Photobiol. B, Biol. 120, 120-9, (2013)
In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells. Ritz R, Scheidle C, Noell S, et al. PLoS ONE 7(12), e51974, (2012)
Effects of hypericin and a chlorin based photosensitizer alone or in combination in squamous cell carcinoma cells in the dark. Besic Gyenge E, Forny P, Lüscher D, et al. Photodiagnosis Photodyn. Ther. 9(4), 321-31, (2012)
Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum perforatum L. plantlets. Qian J, Wu J, Yao B, et al. Acta Biochim. Pol. 59(4), 639-45, (2012)
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells. Šemeláková M, Mikeš J, Jendželovský R, et al. J. Photochem. Photobiol. B, Biol. 117, 115-25, (2012)
Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. Rubio N, Coupienne I, Di Valentin E, et al. Autophagy 8(9), 1312-24, (2012)
Pattern of sensitivity of progressive cutaneous squamous cell carcinoma cells to UVB and oxidative stress-induced cell death. Barrette K, Zutterman N, Van Kelst S, et al. Photochem. Photobiol. Sci. 12(1), 104-10, (2013)
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures. Mañero FJ, Algar E, Martín Gómez MS, et al. Pharm. Biol. 50(10), 1201-9, (2012)
Cell death response of U87 glioma cells on hypericin photoactivation is mediated by dynamics of hypericin subcellular distribution and its aggregation in cellular organelles. Huntosova V, Nadova Z, Dzurova L, et al. Photochem. Photobiol. Sci. 11(9), 1428-36, (2012)
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Francesca Sorrentino et al Bioorg. Med. Chem. 19, 631-41, (2011)
Excited-state properties of hypericin: electronic spectra and fluorescence decay kinetics. Yamazaki, T., et al. J. Phys. Chem. 97, 7870-7875, (1993)
Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing. Theodossiou, T.A., et al. Int. J. Biochem. Cell Biol. 38, 1946-1956, (2006)
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. Buytaert, E., et al. FASEB J. 20, 756-758, (2006)
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