Hypericin from Hypericum perforatum

Papers

Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. Takahashi, I., et al. Biochem. Biophys. Res. Commun. 165, 1207-1212, (1989)

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Antiviral activity of the photoactive plant pigment hypericin. Lopez-Bazzocchi, I., et al. Photochem. Photobiol. 54, 95-98, (1991)

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In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones. Tom Coenye et al Antimicrob. Agents Chemother. 51, 1541-4, (2007)

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Hypericin activates L-type Ca2+ channels in cardiac myocytes. Martin-Pierre Sauviat et al J. Nat. Prod. 70, 510-4, (2007)

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An endophytic fungus from Hypericum perforatum that produces hypericin. Souvik Kusari et al J. Nat. Prod. 71, 159-62, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. Souvik Kusari et al J. Nat. Prod. 72, 1825-35, (2009)

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Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). Adolf Nahrstedt et al J. Nat. Prod. 73, 1015-21, (2010)

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Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Francesca Sorrentino et al Bioorg. Med. Chem. 19, 631-41, (2011)

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Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. Ritz, R., et al. Int. J. Oncol. 30, 659-667, (2007)

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Excited-state properties of hypericin: electronic spectra and fluorescence decay kinetics. Yamazaki, T., et al. J. Phys. Chem. 97, 7870-7875, (1993)

Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. Kocanova, S., et al. Photochem. Photobiol. 82, 720-728, (2006)

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Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing. Theodossiou, T.A., et al. Int. J. Biochem. Cell Biol. 38, 1946-1956, (2006)

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Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. Buytaert, E., et al. FASEB J. 20, 756-758, (2006)

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Antimetastatic activity of the photodynamic agent hypericin in the dark. Blank, M., et al. Int. J. Cancer 111, 596-603, (2004)

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Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules. Miskovsky, P. Curr. Drug Targets 3, 55-84, (2002)

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The multifaceted photocytotoxic profile of hypericin Theodossiou, T.A., et al. Mol. Pharmacol. 6, 1775-1789, (2009)

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Merck 14,4863

Beil. 8,IV,3761