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D-α-Tocopherol polyethylene glycol 1000 succinate

BioXtra, water soluble vitamin E conjugate

Synonym: D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS

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Properties

product line   BioXtra
composition   α-tocopherol, ≥25%
mp   >36 °C
solubility   H2O: soluble1 g/10 mL, clear to faintly turbid, colorless to faintly yellow
cation traces   Al: ≤5 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤5 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
storage temp.   2-8°C

Description

Biochem/physiol Actions

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Tocopherol polyethylene glycol 1000 succinate (TPGS) may be used to create biodegradable polymers and antioxidant surfactants.

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Safety & Documentation

Safety Information

WGK Germany 
2
Flash Point(F) 
>199.4 °F
Flash Point(C) 
>93 °C

Protocols & Articles

Peer-Reviewed Papers

References

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Superparamagnetic iron oxide--loaded poly(lactic acid)-D-α-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent. Prashant C, Dipak M, Yang CT, et al. Biomaterials 31, 5588-5597, (2010)

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Tocopheryl Polyethylene Glycol Succinate as a Safe, Antioxidant Surfactant for Processing Carbon Nanotubes and Fullerenes. Yan A, Von Dem Bussche A, Kane AB, Hurt RH. Carbon 45, 2463-2470, (2007)

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Protective effects of vitamin E forms (α-tocopherol, γ-tocopherol and d-α-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina. Aydemir O, Celebi S, Yilmaz T, et al. Int. Ophthalmol. 25, 283-289, (2004)

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Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic P123 and D-a-tocopheryl polyethylene glycol succinate. Zhao L, Shi Y, Zou S, Sun M, Lil L, Zhail G. J. Biomed. Nanotechnol. 7, 358-365, (2011)

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Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles. Zhao J, Mi Y, and Feng SS Biomaterials 34(13), 3411-21, (2013)

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Trastuzumab-conjugated vitamin E TPGS liposomes for sustained and targeted delivery of docetaxel. Raju A, Muthu MS, and Feng SS Expert Opin. Drug Deliv. 10(6), 747-60, (2013)

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Vitamin E TPGS prodrug micelles for hydrophilic drug delivery with neuroprotective effects. Mi Y, Zhao J, and Feng SS Int. J. Pharm. 438(1-2), 98-106, (2012)

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Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Shen J, Yin Q, Chen L, et al. Biomaterials 33(33), 8613-24, (2012)

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Drug "supersaturation" states induced by polymeric micelles and liposomes: a mechanistic investigation into permeability enhancements. di Cagno M and Luppi B Eur. J. Pharm. Sci. 48(4-5), 775-80, (2013)

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Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. Shen J, Sun H, Xu P, et al. Biomaterials 34(5), 1581-90, (2013)

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Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia. Shneider BL, Magee JC, Bezerra JA, et al. Pediatrics 130(3), e607-14, (2012)

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Polymeric mixed micelles for delivery of curcumin to multidrug resistant ovarian cancer. Saxena V and Hussain MD J. Biomed. Nanotechnol. 9(7), 1146-54, (2013)

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D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells. Neophytou CM, Constantinou C, Papageorgis P, et al. Biochem. Pharmacol. 89(1), 31-42, (2014)

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Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS. Xu P, Yin Q, Shen J, et al. Int. J. Pharm. 454(1), 21-30, (2013)

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Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel. Wang G, Yu B, Wu Y, et al. Int. J. Pharm. 446(1-2), 24-33, (2013)

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Supersaturatable formulations for the enhanced oral absorption of sirolimus. Kim MS, Kim JS, Cho W, et al. Int. J. Pharm. 445(1-2), 108-16, (2013)

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Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats. Ibrahim F, Gershkovich P, Sivak O, et al. Drug Dev. Ind. Pharm. 39(9), 1277-83, (2013)

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Development of curcumin nanocrystal: physical aspects. Rachmawati H, Al Shaal L, Müller RH, et al. J. Pharm. Sci. 102(1), 204-14, (2013)

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Novel lipid based oral formulation of curcumin: development and optimization by design of experiments approach. Pawar YB, Purohit H, Valicherla GR, et al. Int. J. Pharm. 436(1-2), 617-23, (2012)

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Intravitreal administration of dexamethasone-loaded PLGA-TPGS nanoparticles for the treatment of posterior segment diseases. Yang C, Jiang L, Bu S, et al. J. Biomed. Nanotechnol. 9(9), 1617-23, (2013)

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Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology. George M and Ghosh I Eur. J. Pharm. Sci. 48(1-2), 142-52, (2013)

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Enhanced solubility and oral absorption of sirolimus using D-α-tocopheryl polyethylene glycol succinate micelles. Kim MS, Kim JS, Cho WK, et al. Artif. Cells. Nanomed. Biotechnol. 41(2), 85-91, (2013)

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Optimization of formulation and process parameters for the production of nanosuspension by wet media milling technique: effect of Vitamin E TPGS and nanocrystal particle size on oral absorption. Ghosh I, Schenck D, Bose S, et al. Eur. J. Pharm. Sci. 47(4), 718-28, (2012)

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Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro. Wang Y, Guo M, Lu Y, et al. Nanotechnology 23(49), 495103, (2012)

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Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin. Wang T, Yin X, Lu Y, et al. Int. J. Nanomedicine 7, 2325-37, (2012)

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Micelles of TPGS modified apigenin phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation. Munyendo WL, Zhang Z, Abbad S, et al. J. Biomed. Nanotechnol. 9(12), 2034-47, (2013)

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Development and evaluation of tocopherol-rich argan oil-based nanoemulsions as vehicles possessing anticancer activity. Jordan M, Nayel A, Brownlow B, et al. J. Biomed. Nanotechnol. 8(6), 944-56, (2012)

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The effects of topical coenzyme Q10 and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study. Fogagnolo P, Sacchi M, Ceresara G, et al. Ophthalmologica 229(1), 26-31, (2013)

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Enhancement of corneal permeation of riboflavin-5'-phosphate through vitamin E TPGS: a promising approach in corneal trans-epithelial cross linking treatment. Ostacolo C, Caruso C, Tronino D, et al. Int. J. Pharm. 440(2), 148-53, (2013)

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A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons. Fan Z, Wu J, Fang X, et al. Int. J. Pharm. 445(1-2), 141-7, (2013)

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Monitoring the dissolution of Active Pharmaceutical Ingredient and TPGS in real time via IR spectroscopy during the manufacturing of liquid dosage formulation. Šašić S, Palm AS, and Tang D J. Pharm. Biomed. Anal. 70, 273-9, (2012)

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A novel drug-phospholipid complex loaded micelle for baohuoside I enhanced oral absorption: in vivo and in vivo evaluations. Jin X, Zhang ZH, Sun E, et al. Drug Dev. Ind. Pharm. 39(9), 1421-30, (2013)

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Processing challenges with solid dosage formulations containing vitamin E TPGS. Pandey P, Sinko PD, Bindra DS, et al. Pharm. Dev. Technol. 18(1), 296-304, (2013)

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Cyclooxygenase-2/prostaglandin E₂ inducing effects of α-tocopheryl polyethylene glycol succinate in lung epithelial cells. Lee EH and Lim SJ Arch. Pharm. Res. 35(9), 1639-44, (2012)

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Increased absorption of mangiferin in the gastrointestinal tract and its mechanism of action by absorption enhancers in rats. Wang X, Gu Y, Ren T, et al. Drug Dev. Ind. Pharm. 39(9), 1408-13, (2013)

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Vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-based nanomedicine. Zhang Z, Mei L, and Feng SS Nanomedicine (Lond.) 7(11), 1645-7, (2012)

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