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57858 Sigma

Sodium iodoacetate

BioUltra, ≥99.5% (NT)

Synonym: Iodoacetic acid sodium salt

  • CAS Number 305-53-3

  • Linear Formula ICH2COONa

  • Molecular Weight 207.93

  •  Beilstein Registry Number 4009322

  •  EC Number 206-165-7

  •  MDL number MFCD00002686

  •  PubChem Substance ID 57651633

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Properties

InChI Key   AGDSCTQQXMDDCV-UHFFFAOYSA-M
product line   BioUltra
assay   ≥99.5% (NT)
impurities   insoluble matter, passes filter test
  ≤0.5% water
mp   208 °C (dec.)(lit.)
solubility   methanol: 0.1 M at 20 °C clear, colorless
anion traces   chloride (Cl-): ≤100 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤500 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
absorption   absorption0.1M/310 nm, methanol cut-off
storage temp.   −20°C

Description

Other Notes

Sulfhydryl reagent

Application

Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.

Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
AI3675000
Protocols & Articles

Articles

Roar Assay Kits for Studies in Lipoprotein Metabolism

This technical article is a compilation of select fluorescence-based activity assays developed by Roar Biomedical now offered through Sigma-Aldrich in kit format. The methods are well-characterized, ...
Robert Brocia
Roar Biomedical, Inc.
Keywords: Addition reactions, Cardiovascular, Chromatography, Clinical, Detection methods, Drug discovery, Esterifications, Gas chromatography, High performance liquid chromatography, Separation, Thin layer chromatography

Protocols

LCAT Activity Assay Kit

The emission spectrum of the Substrate Reagent has two distinct peaks, 390 nm and 470 nm. The relative intensity of the peaks depends upon the concentration of hydrolyzed and intact substrate present...
Keywords: Titrations

Peer-Reviewed Papers
15

References

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