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59464 Sigma

Trisodium 2-methylcitrate, racemic mixture of diastereomers

≥85% (mixture of diastereomers, NMR)

Synonym: Trisodium 3-carboxy-3-hydroxy-2-methyl-pentanedioate

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Properties

Related Categories Cancer Metabolism, Cancer Research, Cell Biology, Fatty Acid Metabolism in Oncogenesis, Metabolites of Fatty Acid Metabolism in Oncogenesis,
InChI Key   HPLKAWNRQOHUKD-UHFFFAOYSA-K
assay   ≥85% (mixture of diastereomers, NMR)
impurities   ≤5% water

Description

Biochem/physiol Actions

MCA is a diagnostic marker metabolite which cumulates in body fluids of patients suffering from the following inherited metabolic diseases: propionic acidemia (PA), methylmalonic aciduris (MMA), holocarboxylase synthetase deficiency (HCSD). There MCA occurs as a mixture of (2S,3S)- and (2R,3S)-stereoisomers.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

2-Methylcitrate is a component of the 2-methylcitric acid (2-MCA) cycle that utilizes propionate as a source of carbon and energy in bacteria. Trisodium 2-methylcitrate may be used to study this pathway

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Genotype-Phenotype-Relationships in Inborn Errors of Metabolism

More than a century has passed since Archibald Garrod connected the excretion of homogentisic acid in normal and alkaptonuric members of families with an alternative course of metabolism and entitled...
Keywords: Diagnostic, Genetic, Metabolism, Metabolites

New Metabolomics Products

The availability of metabolites is an important element for progress in metabolomics. We have expanded our collection in an effort to provide you with the metabolites needed to advance your research.
Keywords: Metabolites, Metabolomics

Peer-Reviewed Papers
15

References

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